Judge's ruling enables girl to get life-saving lung transplant

10-year-old Sarah Murnaghan, who has stage-end cystic fibrosis, had been deemed ineligible to get a lung from an adult donor
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news

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Chronic airway inflammation and infection drive morbidity and mortality among patients with cystic fibrosis (CF). While Haemophilus influenzae and Staphylococcus aureus predominate in children, the prevalence of Pseudomonas aeruginosa increases as patients age. Other bacteria, including species within the Burkholderia cepacia complex (Bcc), are also more prevalent among adults with CF. Species within the Bcc accelerate lung function decline and can trigger development of “cepacia syndrome,” both before and after lung transplantation.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Authors: Li SS, Tumin D, Krone KA, Boyer D, Kirkby SE, Mansour HM, Hayes D Abstract INTRODUCTION: Survival after lung transplantation lags behind outcomes of other solid organ transplants and complications from lung transplant are the second most common cause of death in cystic fibrosis. Evolving surgical techniques, therapeutics and perioperative management have improved short-term survival after lung transplantation, yet have not translated into significant improvement in long-term mortality. Areas covered: We review risk factors for poor long-term outcomes among patients with cystic fibrosis undergoing lung tran...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
AbstractLung transplantation can offer life-prolonging therapy to children with otherwise terminal end-stage lung disease. However, infectious complications, like those experienced by their adult counterparts, are a significant cause of morbidity and mortality. These include bacteria, viruses, and fungi that infect the patient pretransplant and those that may be acquired from the donor or by the recipient in the months to years posttransplant. An understanding of the approach to the management of each potential infecting organism is required to ensure optimal outcomes. In particular, emphasis on aggressive preoperative man...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
Abstract Lung transplantation can offer life-prolonging therapy to children with otherwise terminal end-stage lung disease. However, infectious complications, like those experienced by their adult counterparts, are a significant cause of morbidity and mortality. These include bacteria, viruses, and fungi that infect the patient pretransplant and those that may be acquired from the donor or by the recipient in the months to years posttransplant. An understanding of the approach to the management of each potential infecting organism is required to ensure optimal outcomes. In particular, emphasis on aggressive preope...
Source: Paediatric Drugs - Category: Pediatrics Authors: Tags: Paediatr Drugs Source Type: research
Cystic fibrosis did not define Claire Wineland. She did.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Claire Wineland, who has cystic fibrosis, needed a double-lung transplant to save her life. But she had a stroke and is now in a medically induced coma.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Chronic Lung Allograft Dysfunction (CLAD) is the main cause of morbidity and mortality after the first year following lung transplantation (LTx). Risk factors of CLAD have been extensively studied, but the ass...
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
A 28-year-old woman with cystic fibrosis presented with painful wrinkling of the palms shortly after immersion in water. She had undergone a bilateral single sequential lung transplant five months before. Pertinently, before this, she had been asymptomatic. Her signs and symptoms were consistent with aquagenic wrinking of the palms. Her immunosuppressive regime included tacrolimus 4.5 mg BD, mycophenolate mofetil 500 mg BD, and prednisolone 10 mg OD. Aquagenic wrinking of the palms is a rare condition in which white papules and plaques and excessive wrinkling of the palmar skin occur within minutes of water exposure.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Semin Respir Crit Care Med 2018; 39: 362-376 DOI: 10.1055/s-0038-1651494Of the nontuberculous mycobacteria (NTMs) causing lung disease, members of the Mycobacterium abscessus complex (MABc) present a formidable obstacle to successful management. This challenge starts from a poorly understood pathogenesis, continues with complicated subspecies variation in treatment response, and extends to the multidrug-resistant nature of these organisms. The disease often necessitates the use of intravenous therapy, toxic drug combinations, and, in some cases, lung resection. Like many NTMs, MABc treatment requires prolonged therapy with...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
Semin Respir Crit Care Med 2018; 39: 383-391 DOI: 10.1055/s-0038-1651495Nontuberculous mycobacteria (NTM) can cause chronic pulmonary infection in susceptible hosts. Individuals with cystic fibrosis (CF), a multisystem disease predominated by progressive structural lung disease, are particularly vulnerable. Only recently have NTM been recognized for their potential to cause lung deterioration in CF patients. The reported prevalence varies widely from 4 to 40%, significantly more common than in the general population, but this varies because of multiple factors including inconsistent screening practices. Mycobacterium absce...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
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