Basophil-expressing genes related with the efficacy of sublingual immunotherapy.

Basophil-expressing genes related with the efficacy of sublingual immunotherapy. J Nippon Med Sch. 2019 Sep 30;: Authors: Gotoh M, Kaminuma O, Nakaya A, Saeki M, Nishimura T, Kitamura N, Hiroi T, Kimihiro Okubo A Abstract Basophils have been implicated not only in allergy pathogenesis, but also in the efficacy of allergen immunotherapy (AIT). We recently conducted a clinical study of sublingual immunotherapy (SLIT) in patients with Japanese cedar pollinosis using a purified cedar allergen. Patients were stratified into the high-responder (HR) and non-responder (NR) groups, and comprehensive microarray analysis was performed on peripheral basophils in the patients from both groups. A total of 153 genes were found to be differentially expressed in the HR and NR patients. The majority of the differentially expressed genes were intracellular molecules and showed higher expression levels in HR patients than NR patients. The mRNA expression levels of the gene encoding D4, zinc, and double plant homeodomain (PHD) fingers family 2 (DPF2) were found to be significantly correlated with copy number variation (CNV). Genetic variation in the DPF2 gene and its expression in basophils is a candidate determinant for SLIT efficacy. PMID: 31564689 [PubMed - as supplied by publisher]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research

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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b05421
Source: Journal of Agricultural and Food Chemistry - Category: Food Science Authors: Source Type: research
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Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
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Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research
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Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research
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