The diagnosis and management of men with low sperm motility
Investigations into infertility typically start with semen analysis. In this article the authors describe the diagnostic criteria, potential causes and approaches to the management of low sperm motility.
Condition: Infertility, Female Intervention: Behavioral: Mindfulness based psychological intervention Sponsor: University Hospital, Geneva Not yet recruiting
Nonobstructive azoospermia (NOA) is a severe form of male infertility. The molecular basis of NOA is still poorly understood. The aim of this study was to explore the associations between single nucleotide polymorphisms (SNPs) of the TATA-box binding protein associated factor 4b (TAF4B) gene and NOA. A total of 100 Han Chinese patients with NOA and 100 healthy men as controls were recruited. Targeted gene capture sequencing was performed. A total of 11 TAF4B SNPs were screened in the NOA and control subjects. Six synonymous and 4 nonsynonymous variants were detected. The c.11G>T (p.G4V) mutation was detected only in NOA...
In this study we addressed this challenge by focusing on the cumulin interface formed by the helix of the GDF9 chain and the fingers of the BMP15 chain. We demonstrate that unique BMP15 finger residues at this site (Arg301, Gly304, His307, and Met369) enable potent activation of the SMAD2/3 pathway. Incorporating these BMP15 residues into latent GDF9 generated a highly potent growth factor, called hereafter Super-GDF9. Super-GDF9 was>1000-fold more potent than WT human GDF9 and 4-fold more potent than cumulin in SMAD2/3-responsive transcriptional assays in granulosa cells. Our demonstration that Super-GDF9 can effective...
ConclusionsInfertile women with UI undergoing assisted reproduction demonstrate different demographic and clinical characteristics compared to those of other causes of infertility, albeit live birth rates are similar.
Authors: Adamczewska D, Slowikowska-Hilczer J, Marchlewska K, Walczak-Jedrzejowska R Abstract INTRODUCTION: There is evidence that disturbed spermatogenesis is associated with impaired Leydig cell function and that it may be the result of testicular dysgenesis during fetal/infant development. Sertoli cell-only syndrome (SCOS) is defined by complete lack of germ cells in the seminiferous epithelium. The pathogenesis of SCOS is still not well understood. The aim of the study is to evaluate testes with SCOS focusing on morphometric signs of testicular dysgenesis and markers of Leydig cell (LC) function in relation to ...
Conclusion: To the best of our knowledge, this research is the first experimental cerebral hydatidosis arisen from larval stage of Echinococcus granulosus in the animal model. PMID: 32489381 [PubMed]
Condition: Infertility Intervention: Procedure: Office hysteroscopy Sponsor: University of North Carolina, Chapel Hill Recruiting
Conditions: Infertility, Male; Testosterone Deficiency Intervention: Other: Exposure: Covid-19 infection Sponsor: Imperial College London Not yet recruiting
Conditions: Infertility; Infertility, Female; IVF; hCG Interventions: Drug: hCG; Diagnostic Test: Ultrasound; Other: Blood test Sponsor: IVI Middle East Fertility Clinic Not yet recruiting
Condition: Infertility, Female Interventions: Drug: Corifollitropin Alfa; Drug: Menotropins Sponsor: Hospital de Clinicas de Porto Alegre Completed