The assessment and management of renal and ureteric stones

To address the management of urolithiasis in the UK, NICE has recently published guidance on the assessment and management of renal and ureteric stones (NG118). In this article, the authors consider the impact of new guidelines in an update on the assessment and management of renal and ureteric stone disease.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: Stone disease Source Type: research

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ConclusionsThere appears to be no association between sex hormones and history of kidney stones. Whether there is a more complex interaction of sex hormone levels and the shared association with factors such as metabolic syndrome requires additional investigation. Further studies matching menopausal status for women are necessary to further investigate the potential  relationship between estrogen and kidney stones.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Renal stones are common, with a lifetime prevalence of 10% in adults. Global incidence is increasing due to increases in obesity and diabetes, with these patient populations being more likely to suffer renal s...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
To screen for the presence of biomarkers involved in tubular injury and kidney damage in children with urolithiasis (RS), and (2) to validate these proteins by ELISA.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
DiscussionThe PUrE trial aims to provide robust evidence on health status, quality of life, clinical outcomes and resource use to directly inform choice and National Health Service provision of the three treatment options.Trial registrationISRCTN:ISRCTN98970319. Registered on 11 November 2015.
Source: Trials - Category: Research Source Type: clinical trials
Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic s...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research
ConclusionThe majority of this study cohort had back pain of benign cause. Some red flags were associated with greater risk of serious pathology, others were not. Further evidence regarding red flags and their association with serious pathology is required, to better inform clinical guidelines.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
AbstractPurposeStandard prone position (PP) during percutaneous nephrolithotomy (PNL) has multiple drawbacks. We aimed to compare PNLs performed in split-leg (SL) modified lateral position (MLP) and those performed in standard PP.MethodsA prospective, randomized, unblind, double arm trial was conducted at a tertiary care academic medical center in Egypt, between November 2017 and October 2019. Adult patients with renal stones undergoing PNL were included. According to renal anatomy and stone complexity, stratified randomization was performed and study participants were allocated into either SL-MLP group or PP group. The st...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Abstract The aim of present research work was to design, fabricate, optimize, and evaluate allopurinol (ALLO)-loaded bovine serum albumin nanoparticles (ABNPs) for kidney targeting of the drug and exploring the potential of fabricated ABNPs for management of hyperuricemia-related nephrolithiasis. ABNP formulation was prepared by employing desolvation technique, and its optimization was conducted by 2-factor-3-level central composite design (CCD) in order to achieve minimum particle size (PSA) and polydispersity index (PDI), maximum entrapment efficiency (EE), and zeta potential (ZP). Further, the optimized formula...
Source: AAPS PharmSciTech - Category: Drugs & Pharmacology Authors: Tags: AAPS PharmSciTech Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Journal of Endourology, Ahead of Print.
Source: Journal of Endourology - Category: Urology & Nephrology Authors: Source Type: research
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