The athlete's heart

Athletes undergoing intensive training can exhibit cardiac changes that overlap with cardiomyopathy. Here the authors review cardiac changes that can occur in athletes and how to distinguish between normal adaptations and those that may signal pathology that can result in sudden death.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: Cardiovascular medicine Source Type: research

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Condition:   Cardiomyopathy, Hypertrophic Obstructive Interventions:   Drug: CT-20;   Drug: Placebo Sponsor:   Celltrion Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: The protein kinases TBK1 and IKKε inhibitor Amlexanox can improve cardiac function in rats after AMI, reduce myocardial inflammatory response, reduce myocardial apoptosis, and then exert myocardial protection in vivo. PMID: 32495612 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
The phenomenon of high signal intensity on T2-weighted imaging of cardiac magnetic resonance in hypertrophic cardiomyopathy (HCM) has been previously studied. However, the underlying histopathologic mechanism remains unclear. Elevated cardiac troponin can be detected in some HCM patients. A reasonable hypothesis is that high myocardial T2 signal is a potential marker of myocardial injury in HCM. We sought to investigate the association between cardiac troponin and the extent of high T2 signals in HCM patients. Forty-four HCM patients underwent 3.0T cardiac magnetic resonance scanning. On T2-weighted images, the number of ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Publication date: Available online 3 June 2020Source: Revista Española de Cardiología (English Edition)Author(s): Juan Jiménez-Jáimez, Diego Segura-Rodríguez, Francisco Bermúdez-Jiménez
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Coronavirus disease (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The symptoms of the disease range from asymptomatic to mild respiratory symptoms and even potentially life-threatening cardiovascular and pulmonary complications. Cardiac complications include acute myocardial injury, arrhythmias, cardiogenic shock and even sudden death. Furthermore, drug interactions with COVID-19 therapies may place the patient at risk for arrhythmias, cardiomyopathy and sudden death.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Review Source Type: research
Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigates reduced transcription. As a consequence, reduced levels of frataxin protein lead to mitochondrial iron accumulation, oxidative stress, and ultimately cell death; particularly in dorsal root ganglia (DRG) sensory neurons and the dentate nucleus of the cerebellum. In addition to neurological disability, FRDA is associated with cardiomyopathy, diabetes mellitus, and skeletal deformities. Currently there is no effective treatment for FRDA and ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 3 June 2020Source: The Veterinary JournalAuthor(s): J. Eberhard, G. Wess
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Sepsis-induced cardiomyopathy (SIC) is associated with increased patient mortality. At present, there are no specific therapies for SIC. Previous studies have reported increased reactive oxygen species (ROS) and mitochondrial dysfunction during SIC. However, a unifying mechanism remains to be defined. We hypothesized that PKCdelta is required for abnormal calcium handling and cardiac mitochondrial dysfunction during sepsis and that genetic deletion of PKCdelta would be protective. Polymicrobial sepsis induced by cecal ligation and puncture (CLP) surgery decreased the ejection fraction of wild-type (WT) mice but not PKCdelt...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conditions:   Pacemaker DDD;   His Bundle Pacing;   LBB Area Pacing;   Pacing-Induced Cardiomyopathy;   Left Bundle-Branch Block;   ICD Intervention:   Device: cardiac implantable electronic device (CIED) implantation Sponsors:   Klinikum-Fuerth;   University of Erlangen-Nürnberg;   University of Trieste Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We present a case with a close temporal association of the first diagnosis of multiple sclerosis and stress cardiomyopathy.
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
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