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Hematopoietic Allograft Impacts Lung Function, InflammationHematopoietic Allograft Impacts Lung Function, Inflammation

A new study reports that allogeneic hematopoietic stem cell transplant recipients may experience decreased lung function and increased pulmonary inflammation. BMC Pulmonary Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

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This article reviews the advantages and limitations of each technique used over the past few decades in clinical practice. The main limitation seems to be the capacity for tracheal tissue regeneration. The physiopathology behind this has yet to be fully understood. Research on stem cells sparked much interest and was thought to be a revolutionary technique; however, the poor long-term results of this approach highlight that there is a long way to go in this research field. Currently, an autologous tissue composite, with or without a tracheal allograft, is the only long-term working solution for every aetiology, despite its...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Reviews Source Type: research
CONCLUSIONS: SMGs and basal SC compartments are depleted in large and/or small airways of lung allografts, and basal SC proliferative capacity declines with progression of disease and phenotypic changes. Global airway SC depletion may be a mechanism for pulmonary allograft failure. PMID: 29236513 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might at...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Source Type: research
Immunomodulatory agents provide the solution for complex therapeutics such as allograft tolerance from both, hematopoietic stem cell and solid organ transplantation. However, these agents - while disease modifying - have profound immune suppressive side effects, often leaving patients at high risk for life-threatening infections. In fact, fungal pathogens such as Candida species, which now account for almost 10% of intensive care unit admissions across the United States with mortality rates near 90%.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The aim of this study was to investigate the effect of secretome from bone marrow derived stem cells (BMSC) on acute lung rejection in rat lung allotransplantation model. Lung allotransplantation was performed from male BN donor to male Fisher F344 rats. Rat BMSC were grown in serum free condition and the supernatant bone marrow stem cells derived conditioned media (BMSC-cm) was collected. Recipients were instilled BMSC-cm intra tracheal every day for 5 days. Group A (n=5) received control media and low dose CsA (2.5 mg/kg bw ip) and group B (n=5) BMSC-cm and a low dose CsA, for 5 days post-transplant. Graft function was a...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 8.2 Transplantation Source Type: research
HLA-E(⁎)01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence. J Immunol Res. 2016;2016:1910852 Authors: Di Cristofaro J, Pelardy M, Loundou A, Basire A, Gomez C, Chiaroni J, Thomas P, Reynaud-Gaubert M, Picard C Abstract Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. Two nonsynonymous alleles, HLA-E(⁎)...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
This article is protected by copyright. All rights reserved. Human mesenchymal stromal cells were isolated from healthy parenchymal lung tissue (LT‐MSCs, n=24, 4 samples from 6 patients) and lung allograft bronchoalveolar lavage fluid (BAL‐MSCs, n=12, 1 sample from 12 patients) and gene expression was analysed by microarray. Using Significance Analysis of Microarrays, 105 differentially expressed genes were identified. When visualised as a hierarchical cluster, MSC populations segregate into two distinct groups when samples and probes are clustered using Pearson correlation. Genes that were upregulated in BAL‐MSCs i...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
Abstract: Obliterative bronchiolitis (OB) is a clinical syndrome marked by progressive dyspnea and cough with the absence of parenchymal lung disease on radiographic studies. Pulmonary function testing reveals an obstructive ventilatory defect that is typically not reversed by inhaled bronchodilator. Transbronchial biopsies are insufficiently sensitive to achieve diagnosis, and in most cases, clinical, physiological, and radiological data obviate the need for the increased risk associated with open lung biopsy. This diagnosis has been documented in a variety of exposures, including fumes from flavoring plants, smoke from b...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
Until recently, it was generally thought that bronchiolitis obliterans syndrome (BOS), which is a type of obstructive lung disease with a dismal outcome, was the sole form of chronic lung allograft dysfunction (CLAD) occurring after lung transplantation. However, recent publications reported that some patients experience a restrictive form of chronic lung complication that has been termed restrictive allograft syndrome (RAS) [1]. Approximately one-third of patients with CLAD after lung transplantation can be classified as having RAS [2, 3]. This distinct form of CLAD is considered to be an important entity and has features...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung structure and function Original Articles: Research letters Source Type: research
This study demonstrates that IDO gene transfer into engineered lung allograft tissues significantly attenuates acute allograft damage suggesting local therapy with IDO as a strategy to reduce the need for systemic immunosuppression and, thereby, its side effects. PMID: 26506443 [PubMed - as supplied by publisher]
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
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