Hematopoietic Allograft Impacts Lung Function, InflammationHematopoietic Allograft Impacts Lung Function, Inflammation

A new study reports that allogeneic hematopoietic stem cell transplant recipients may experience decreased lung function and increased pulmonary inflammation. BMC Pulmonary Medicine
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

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Introduction: Umbilical cord blood (UCB) grafts are the only option for a significant minority of patients who require hematopoietic stem cell transplantation (HSCT) but lack a suitable related or unrelated donor. While UCB can serve as a suitable 'off the shelf' graft for many patients, units with the best HLA match often contain low and sometimes insufficient numbers of CD34+ cells for use in transplantation, particularly for adult patients. Furthermore, UCB grafts contain lower CD34+ cells number compared to BM or PBSC grafts, which leads to longer engraftment times and a higher risk of graft failure. BM and PBSC grafts...
Source: Blood - Category: Hematology Authors: Tags: 701. Experimental Transplantation: Basic Biology, Pre-Clinical Models Source Type: research
Authors: Kawai H, Tsujigiwa H, Siar CH, Nakano K, Takabatake K, Fujii M, Hamada M, Tamamura R, Nagatsuka H Abstract Background: The tumor microenvironment and its stromal cells play an important role in cancer development and metastasis. Bone marrow-derived cells (BMDCs), a rich source of hematopoietic and mesenchymal stem cells, putatively contribute to this tumoral stroma. However their characteristics and roles within the tumor microenvironment are unclear. In the present study, BMDCs in the tumor microenvironment were traced using the green fluorescent protein (GFP) bone marrow transplantation model. Methods: C...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article reviews the advantages and limitations of each technique used over the past few decades in clinical practice. The main limitation seems to be the capacity for tracheal tissue regeneration. The physiopathology behind this has yet to be fully understood. Research on stem cells sparked much interest and was thought to be a revolutionary technique; however, the poor long-term results of this approach highlight that there is a long way to go in this research field. Currently, an autologous tissue composite, with or without a tracheal allograft, is the only long-term working solution for every aetiology, despite its...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Reviews Source Type: research
CONCLUSIONS: SMGs and basal SC compartments are depleted in large and/or small airways of lung allografts, and basal SC proliferative capacity declines with progression of disease and phenotypic changes. Global airway SC depletion may be a mechanism for pulmonary allograft failure. PMID: 29236513 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Primary graft dysfunction (PGD) is considered to be the end result of an inflammatory response targeting the new lung allograft after transplant. Previous research has indicated that MAPC cell therapy might at...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Source Type: research
Immunomodulatory agents provide the solution for complex therapeutics such as allograft tolerance from both, hematopoietic stem cell and solid organ transplantation. However, these agents - while disease modifying - have profound immune suppressive side effects, often leaving patients at high risk for life-threatening infections. In fact, fungal pathogens such as Candida species, which now account for almost 10% of intensive care unit admissions across the United States with mortality rates near 90%.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The aim of this study was to investigate the effect of secretome from bone marrow derived stem cells (BMSC) on acute lung rejection in rat lung allotransplantation model. Lung allotransplantation was performed from male BN donor to male Fisher F344 rats. Rat BMSC were grown in serum free condition and the supernatant bone marrow stem cells derived conditioned media (BMSC-cm) was collected. Recipients were instilled BMSC-cm intra tracheal every day for 5 days. Group A (n=5) received control media and low dose CsA (2.5 mg/kg bw ip) and group B (n=5) BMSC-cm and a low dose CsA, for 5 days post-transplant. Graft function was a...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 8.2 Transplantation Source Type: research
HLA-E(⁎)01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence. J Immunol Res. 2016;2016:1910852 Authors: Di Cristofaro J, Pelardy M, Loundou A, Basire A, Gomez C, Chiaroni J, Thomas P, Reynaud-Gaubert M, Picard C Abstract Lung transplantation (LTx) is a valid therapeutic option for selected patients with end-stage lung disease. HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. Two nonsynonymous alleles, HLA-E(⁎)...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
This article is protected by copyright. All rights reserved. Human mesenchymal stromal cells were isolated from healthy parenchymal lung tissue (LT‐MSCs, n=24, 4 samples from 6 patients) and lung allograft bronchoalveolar lavage fluid (BAL‐MSCs, n=12, 1 sample from 12 patients) and gene expression was analysed by microarray. Using Significance Analysis of Microarrays, 105 differentially expressed genes were identified. When visualised as a hierarchical cluster, MSC populations segregate into two distinct groups when samples and probes are clustered using Pearson correlation. Genes that were upregulated in BAL‐MSCs i...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
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