Muscular hypotonia as an onset manifestation of Tuberculosis meningitis in an HIV ‐negative patient

Muscular hypotonia is considered as one of the rarest forms of initial onset signs of TBM, in addition to aphasia and hyponatremia, the awareness of those rare onset signs, a well ‐conducted diagnostic approach and early treatment can improve the outcome. AbstractMuscular hypotonia is considered as one of the rarest forms of initial onset signs of TBM, in addition to aphasia and hyponatremia, the awareness of those rare onset signs, a well ‐conducted diagnostic approach and early treatment can improve the outcome.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research

Related Links:

ConclusionThe study signifies the development of a potent therapeutic agent comprising of a complex of anti-TB agent (fatty acids) and antioxidants (carotenoids) from the CGF-extracted spent biomass of C. vulgaris.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Bill Gates, who is currently on a three-day visit to India, said: "Our biggest work has been broadly in the health area helping to get new vaccines introduced, helping to look at innovations in some of the disease-specific areas, like tuberculosis or visceral leishmaniasis (VL) or lymphatic filariasis (LF)."
Source: The Economic Times - Category: Consumer Health News Source Type: news
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Pooja Gopal, Thomas DickAbstractDrug induced degradation of a target protein is a novel concept in drug discovery. Traditionally drugs modulate activity, as opposed to abundance, of their targets. Degradation inducing ligands act catalytically. Thus, one advantage of target degradation over the classical on-target mechanism is that lower drug concentration may be sufficient to cause the desired cellular effects. The first promoters of target degradation were discovered unintentionally: it turned out that some d...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Neelagandan Kamariah, Priya Ragunathan, Joon Shin, Wuan-Geok Saw, Chui-Fann Wong, Thomas Dick, Gerhard GrüberAbstractThe causative agent of Tuberculosis (TB) Mycobacterium tuberculosis (Mtb) encounters unfavourable environmental conditions in the lungs, including nutrient limitation, low oxygen tensions and/or low/high pH values. These harsh conditions in the host triggers Mtb to enter a dormant state in which the pathogen does not replicate and uses host-derived fatty acids instead of carbohydrates as an ...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 15 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ludovica Mascolo, Dirk BaldAbstractThe branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of ...
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
[WHO] Children in 19 Northern states to be vaccinated in largescale campaign implemented by the Government of Nigeria and WHO with Gavi support
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 16 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Renan Barros Domingues, Márcio Vega dos Santos, Fernando Brunale Vilela de Moura Leite, Carlos SenneAbstractThe precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific. Conventional methods for bacterial meningitis lack sensitivity or take too long for a final result. Therefore, other methods for rapid and accurate diagnosis of central nervous system infections are required. FilmArray meningitis/encephalitis (ME) panel ...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
In conclusion, CASAC adjuvant has great potential to enhance immunogenicity elicited against HspX antigen, which could be an alternative regimen to improve the efficacy of future therapeutic vaccine against Mycobacterium tuberculosis.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 November 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): I. Stoica, A. Muntean, M.B. McDermott, F.M.J. QuinnAbstractXanthogranulomatous pyelonephritis (XGP) is an uncommon chronic destructive granulomatous inflammation of the kidney that can sometimes mimic other renal pathologies like tumours or infections. For this reason, it is also called “the great imitator”.This is the case of a 7-year old girl that presented to the hospital with right hip pain and a suspicious right sided abdominal lesion, thought initially to be a Wilms’ tumour and then an appe...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
ConclusionsIdiopathic granulomatous hypophysitis, a rare inflammatory disease of the pituitary gland, is a diagnosis of exclusion for which both medical and surgical management are reported in the literature. We present a case of idiopathic granulomatous hypophysitis who was symptom free with no complications of hypopituitarism following its transsphenoidal resection after 9  months of follow-up.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
More News: Aphasia | General Medicine | Men | Meningitis | Tuberculosis