Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Bone Marrow Transplantation, Published online: 01 October 2019; doi:10.1038/s41409-019-0705-zSinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the most severe forms result in multiorgan dysfunction and are associated with a high mortality rate (>80%). Therefore, careful surveillance may allow early detection of SOS/VOD, particularly as the licensed available drug is proven to be effective and reduce mortality. The aim of this work is to propose an international consensus guideline for the treatment and prevention of SOS/VOD in adult patients, on behalf of an international expert group.

Source: Bone Marrow Transplantation - September 30, 2019 Category: Hematology Authors: Mohamad Mohty Florent Malard Manuel Abecasis Erik Aerts Ahmed S. Alaskar Mahmoud Aljurf Mutlu Arat Peter Bader Frederic Baron Grzegorz Basak Ali Bazarbachi Didier Blaise Fabio Ciceri Selim Corbacioglu Jean-Hugues Dalle Fiona Dignan Takahiro Fukuda Anne Hu Source Type: research