Mutated CEACAMs Disrupt Transforming Growth Factor beta Signaling and Alter the Intestinal Microbiome to Promote Colorectal Carcinogenesis

We studied interactions among proteins of the carcinoembryonic antigen related cell adhesion molecule (CEACAM) family, which interact with microbes, and transforming growth factor beta (TGFB) signaling pathway, which is often altered in colorectal cancer cells. We investigated mechanisms by which CEACAM proteins inhibit TGFB signaling and alter the intestinal microbiome to promote colorectal carcinogenesis.

Source: Gastroenterology - September 30, 2019 Category: Gastroenterology Authors: Shoujun Gu, Sobia Zaidi, Md. Imtaiyaz Hassan, Taj Mohammad, Tathiane M. Malta, Houtan Noushmehr, Bryan Nguyen, Keith A. Crandall, Jigisha Srivastav, Vincent Obias, Paul Lin, Bao-Ngoc Nguyen, Michael Yao, Ren Yao, Charles Hadley King, Raja Mazumder, Bibhut Source Type: research