Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention

Conclusion: Chemical modification of the FAPI framework enabled enhanced FAP binding and improved pharmacokinetics in most of the derivatives, resulting in high-contrast images. Moreover, higher doses of radioactivity can be delivered while minimizing damage to healthy tissue, which may improve therapeutic outcome.

Source: Journal of Nuclear Medicine - September 30, 2019 Category: Nuclear Medicine Authors: Loktev, A., Lindner, T., Burger, E.-M., Altmann, A., Giesel, F., Kratochwil, C., Debus, J., Marme, F., Jager, D., Mier, W., Haberkorn, U. Tags: Basic Source Type: research