Preclinical Pharmacokinetics and Dosimetry Studies of 124I/131I-CLR1404 for Treatment of Pediatric Solid Tumors in Murine Xenograft Models

Conclusion: CLR1404 is a suitable theranostic scaffold for dosimetry and therapy with potentially broad applicability in pediatric oncology. Given the ongoing clinical trials for CLR 131 in adults, these data support the development of pediatric clinical trials and provide detailed dosimetry that may lead to improved MRT treatment planning.

Source: Journal of Nuclear Medicine - September 30, 2019 Category: Nuclear Medicine Authors: Marsh, I. R., Grudzinski, J., Baiu, D. C., Besemer, A., Hernandez, R., Jeffery, J. J., Weichert, J. P., Otto, M., Bednarz, B. P. Tags: Basic Source Type: research