68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice

Conclusion: Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated with increased cancer growth and metastasis, may also have important regulatory roles in controlling the tumor microenvironment.

Source: Journal of Nuclear Medicine - September 30, 2019 Category: Nuclear Medicine Authors: Siitonen, R., Peuhu, E., Autio, A., Liljenback, H., Mattila, E., Metsala, O., Kakela, M., Saanijoki, T., Dijkgraaf, I., Jalkanen, S., Ivaska, J., Roivainen, A. Tags: Basic Source Type: research