Mechanisms underlying the hyperexcitability of CA3 and dentate gyrus hippocampal neurons derived from bipolar disorder patients.
Approximately one in every 50-100 people is affected with bipolar disorder (BD), making this disease a major economic burden. The introduction of the induced pluripotent stem cells (iPSCs) methodology enabled better modeling of this disorder.
Source: Biological Psychiatry - Category: Psychiatry Authors: Shani Stern, Anindita Sarkar, Tchelet Stern, Arianna Mei, Ana P.D. Mendes, Yam Stern, Gabriela Goldberg, Dekel Galor, Thao Nguyen, Lynne Randolph-Moore, Yongsung Kim, Guy Rouleau, Anne Bang, Martin Alda, Renata Santos, Maria C. Marchetto, Fred H. Gage Tags: Archival Report Source Type: research