Viruses, Vol. 11, Pages 859: Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process

Viruses, Vol. 11, Pages 859: Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process Viruses doi: 10.3390/v11090859 Authors: Claire Muslin Alice Mac Kain Maël Bessaud Bruno Blondel Francis Delpeyroux RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologous intertypic recombinant enteroviruses that were observed in nature would be the final products of a multi-step process, during which precursor nonhomologous recombinant genomes are generated through an initial inter-genomic RNA recombination event and can then evolve into a diversity of fitter homologous recombinant genomes over subsequent intra-genomic rearrangements. Moreover, these experimental studies demonstrated that the enterovirus genome could be defined as a combination of genomic modules that can be preferentially exchanged through recombination, and enabled defining the boundaries of these recombination modules. These results prov...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research