Viruses, Vol. 11, Pages 859: Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process

Viruses, Vol. 11, Pages 859: Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process Viruses doi: 10.3390/v11090859 Authors: Claire Muslin Alice Mac Kain Maël Bessaud Bruno Blondel Francis Delpeyroux RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologous intertypic recombinant enteroviruses that were observed in nature would be the final products of a multi-step process, during which precursor nonhomologous recombinant genomes are generated through an initial inter-genomic RNA recombination event and can then evolve into a diversity of fitter homologous recombinant genomes over subsequent intra-genomic rearrangements. Moreover, these experimental studies demonstrated that the enterovirus genome could be defined as a combination of genomic modules that can be preferentially exchanged through recombination, and enabled defining the boundaries of these recombination modules. These results ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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Carter Roberts’ motorized wheelchair didn’t arrive until the day he died. It had been a long time coming and his parents had fought hard to get it. The chair cost more than $32,000 and the insurance companies wouldn’t cover it, so the family went to court. One insurer eventually agreed to pay for some components of the chair but not the whole thing. And then none of it mattered anyway. On Sept. 22, 2018, the Roberts’ doorbell rang and the chair was delivered. Also on Sept. 22, 2018, Carter died, just three months shy of his sixth birthday. He had been largely paralyzed for the final two years of his...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease viruses Source Type: news
The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poliomyelitis returns to the Philippines (Mashable, virology blog) EEE in the USA (Am J Trop Med Hyg) Chemokine helps HIV-1 release (eLIFE) Image credit Letters read o...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Viruses, Vol. 11, Pages 424: Environmental Surveillance for Poliovirus and Other Enteroviruses: Long-Term Experience in Moscow, Russian Federation, 2004–2017 Viruses doi: 10.3390/v11050424 Authors: Ivanova Yarmolskaya Eremeeva Babkina Baykova Akhmadishina Krasota Kozlovskaya Lukashev Polio and enterovirus surveillance may include a number of approaches, including incidence-based observation, a sentinel physician system, environmental monitoring and acute flaccid paralysis (AFP) surveillance. The relative value of these methods is widely debated. Here we summarized the results of 14 ye...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study was carried to i) investigate the circulation and genetic diversity of NPEV and polio vaccine isolates recovered from healthy children and Acute Flaccid Paralysis ( AFP) patients, ii) evaluate the occurrence of genetic recombination among EVs belonging to theEnterovirus C species (including PVs) and iii) identify the virological factors favoring multiple emergences of cVDPVs in DR Congo. The biological material considered in this study included i) a collection of 91 Sabin-like PVs, 54 cVDPVs and 150 NPEVs isolated from AFP patients between 2008 and 2012 in DR Congo and iii) a collection of 330 stool specimens co...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
(NEW YORK) — One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping. It was the first sign of an unfolding nightmare. Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe. “It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.” Joey, who survived but still suffers some of the effects, was one of 228...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized illness medical onetime Source Type: news
(The Translational Genomics Research Institute) Using multiple genomic sequencing tests, TGen identified a specific non-polio enterovirus -- EV-D68 -- among at least four children, according to a study published today in the scientific journal mBio. The finding is significant because AFM cases are continuing to increase and there has been no official recognition that this disease is being caused by EV-D68, which limits the research community's ability to develop preventative measures, such as new vaccines.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
A rare, polio-like illness continues to spread across the United States, puzzling and concerning health officials who are investigating the mysterious condition. So far this year, the Centers for Disease Control and Prevention (CDC) has reported a total of 72 confirmed cases of acute flaccid myelitis (AFM) in 24 states, including clusters in Minnesota, Pennsylvania and Colorado. Ninety percent of confirmed diagnoses were in children younger than 18, according to the CDC. The agency is investigating another 119 patients in connection with the disease, which causes symptoms including sudden arm and leg weakness, loss of musc...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Infectious Disease onetime Source Type: news
The Centers for Disease Control and Prevention (CDC) has so far this year recorded 127 suspected cases of a polio-like nervous system disorder that can cause paralysis, fueling an ongoing investigation into an outbreak of the rare disease. Of those 127 illnesses, 62 cases in 22 states are confirmed to be acute flaccid myelitis (AFM), the CDC said Tuesday. The CDC recorded only 33 confirmed cases of the severe condition — which typically affects kids and can result in muscle weakness or paralysis, respiratory failure and even death — during all of last year, though there were 149 cases the year before. “W...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Minnesota onetime Source Type: news
Six Minnesota children have recently been diagnosed with a rare, polio-like nervous system disorder that can cause paralysis — and the cluster is concerning and puzzling state health officials. The Minnesota Department of Health (MDH) has since mid-September received a half-dozen reports of children with acute flaccid myelitis (AFM), a severe condition that typically affects kids and can result in muscle weakness or paralysis, respiratory failure and even death, according to a statement. All of the Minnesota patients are younger than 10, and cases have been reported in northeastern and central parts of the state, as ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Minnesota onetime Source Type: news
Three more children have come down with a polio-like nervous system disorder that can cause paralysis, fueling an ongoing investigation into an outbreak of the rare disease. Three children are being treated for suspected cases of acute flaccid myelitis (AFM) at UPMC Children’s Hospital of Pittsburgh, ABC News reports. The new patients join a cluster of cases in Minnesota and another in Colorado. As of September 30, the Centers for Disease Control and Prevention (CDC) had this year recorded 38 confirmed cases of the severe condition, which typically affects kids and can result in muscle weakness or paralysis, respirat...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Minnesota onetime Source Type: news
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