Heme binding to human CLOCK affects interactions with the E-box [Chemistry]

The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as well as some bacteria. In mammals, the clock regulates the sleep–wake cycle via 2 basic helix–loop–helix PER-ARNT-SIM (bHLH-PAS) domain proteins—CLOCK and BMAL1. There is emerging evidence to suggest that heme affects circadian control, through...

Source: Proceedings of the National Academy of Sciences - September 30, 2019 Category: Science Authors: Samuel L. Freeman, Hanna Kwon, Nicola Portolano, Gary Parkin, Umakhanth Venkatraman Girija, Jaswir Basran, Alistair J. Fielding, Louise Fairall, Dimitri A. Svistunenko, Peter C. E. Moody, John W. R. Schwabe, Charalambos P. Kyriacou, Emma L. Raven Tags: Biological Sciences Source Type: research