Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic {beta} cells [Cell Biology]

Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinophagy and autophagy are instead responsible to deliver damaged or old granules to acidic lysosomes for intracellular degradation. However, excessive consumption of insulin granules can impair β cell function and cause diabetes. Atp6ap2...

Source: Proceedings of the National Academy of Sciences - September 30, 2019 Category: Science Authors: Katrina J. Binger, Martin Neukam, Sudhir Gopal Tattikota, Fatimunnisa Qadri, Dmytro Puchkov, Diana M. Willmes, Sabrina Wurmsee, Sabrina Geisberger, Ralf Dechend, Klemens Raile, Thomas Kurth, Genevieve Nguyen, Matthew N. Poy, Michele Solimena, Dominik N. M Tags: Biological Sciences Source Type: research