Inside-out signaling through FAK-integrin axis may regulate circulating cancer cell metastatic adhesion [Biological Sciences]

In PNAS, Chang et al. (1) call attention to the function of focal adhesion kinase (FAK) in mediating inside-out signaling regulating immune cell adhesion to the endothelium by elegantly studying the FAK–RAP1–RIAM–talin pathway for feedforward inside-out signaling through integrin described by Lagarrigue (2). Chang et al. solve the crystal structure...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Letters, Front Matter-Letters-Set Free Source Type: research