Reply to Ruprecht and Mayer: Unearthing genomic fossils in the pathogenesis of multiple sclerosis Biological Sciences

This Reply refers to the Letter by Ruprecht and Mayer titled “On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions” (1). In their Letter, the authors confirm the specificity of the monoclonal antibody GN-MAb_03 (3B2H4) that we used to detect the pHERV-W ENV protein in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Letters, Front Matter-Letters-Set Free Source Type: research

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ConclusionFurther studies are needed to evaluate the molecular mechanisms involved in the behaviour of MLT in EAE, and to quantify other cytokines in different biological media in order for MLT to be considered an anti-inflammatory agent capable of regulating MS.ResumenIntroducciónLa esclerosis múltiple (EM) es una enfermedad crónica desmielinizante autoinmune del sistema nervioso central (SNC) que produce neuroinflamación, un modelo es la encefalitis autoinmune experimental (EAE). La EM ha sido tratada con interferón beta (IFN-beta) y acetato de glatiramero (AG). Se ha descrito que la me...
Source: Neurologia - Category: Neurology Source Type: research
ConclusionsT cells that reach the bloodstream of fingolimod-treated patients with multiple sclerosis may contribute to the neuroprotective effect of this therapy by increased secretion of brain-derived neurotrophic factor. This mechanism of action of fingolimod in patients with multiple sclerosis has not been previously reported.
Source: CNS Drugs - Category: Neurology Source Type: research
Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Additionally, evidence for PRR signaling in non-immune cells and PRR responses to host-derived endogenous ligands has also revealed new pathways controlling the development of CNS autoimmunity. Many PRRs remain uncharacterized in MS and EAE, and understanding the distinct triggers and functions of PRR signa...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsMigraine may affect quality of life similarly to early stages of RRMS. Bio-psycho-socio-medical understanding of the two diseases and their impact on patients QoL should be reconsidered.
Source: Neurological Sciences - Category: Neurology Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
The change comes after two highly publicized cases in which young epileptic patients depended on the treatments.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cannabis Foods and Products Epilepsy Medical Marijuana Multiple Sclerosis Drugs (Pharmaceuticals) Chemotherapy England Wales Source Type: news
Children with two rare life-threatening forms of epilepsy will now have access to the drug Epidyolex, which helps to reduce seizures. Patients with MS will be offered a cannabis-based spray.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 10 November 2019Source: Neuroscience LettersAuthor(s): Wendi Ma, Mingliang Zhang, Shuqing Liu, Mengru Wang, Yamin Shi, Ting Yang, Xing Li, Lin ZhuAbstractExpression of sphingosine/sphingosine 1-phosphate (SPH/S1P) in resident cells of the central nervous system plays an important role in the pathogenesis of multiple sclerosis (MS). Accumulated evidence has shown the protective effects of S1P receptor modulators on MS and its animal model, experimental autoimmune encephalomyelitis (EAE). However, effective therapies to regulate SPH/S1P molecules themselves have not been well addressed. Our...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Politicians running scared of big pharma and the taboo around cannabis are blocking access to these vital drugsThat the government will allow a few serious epilepsy and multiple sclerosis sufferers to getcannabidiol medicine to relieve their symptoms is good news. That is all that can be said. Once more a decision emerges from the caverns of Britain ’s NHS that reveals the evils of a politicised, centralised, deadened health service.Related:Legalisation of cannabis in the UK would help protect its users from harm | James NichollsContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Cannabis Drugs Society NHS Health Epilepsy UK news Science Pharmaceuticals industry Business David Nutt Source Type: news
The feeling of abandonment can span through all types of relationships and in this episode, we focus on friendships. Have you ever had a close friend abandon you or have you ever exited a friendship without notice? The emotions and actions surrounding the abandonment of friends can be complex and hurtful, but they are very real and can hurt deeply.  In this episode, Jackie recounts friendships that were very important to her and how she’s handling the loss of them. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who live...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Family Friends General Grief and Loss Not Crazy Podcast Relationships Source Type: blogs
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