Nephrotic syndrome is associated with increased plasma K+ concentration, intestinal K+ losses and attenuated urinary K+ excretion - studies in rats and humans.

Nephrotic syndrome is associated with increased plasma K+ concentration, intestinal K+ losses and attenuated urinary K+ excretion - studies in rats and humans. Am J Physiol Renal Physiol. 2019 Sep 30;: Authors: Ydegaard R, Svenningsen P, Bistrup C, Andersen RF, Stubbe J, Buhl KB, Marcussen N, Hinrichs GR, Iraqi H, Zamani R, Dimke H, Jensen BL Abstract The present study tested the hypotheses that nephrotic syndrome (NS) leads to renal K+ loss due to augmented ENaC activity followed by down-regulation of renal K+- secretory pathways by suppressed aldosterone. The hypotheses were addressed by determining K+-balance and kidney abundance of K+- and Na+ transporter proteins in puromycin aminonucleoside (PAN)-induced rat nephrosis. Effect of amiloride and angiotensin II-AT1 and mineralocorticoid receptor (MR) antagonists were tested. Glucocorticoid-dependent MR activation was tested by suppression of endogenous glucocorticoid with dexamethasone. Urine and plasma samples were obtained from pediatric NS-patients in acute and remission-phase. PAN-nephrotic rats had ENaC dependent Na+ retention; displayed lower renal K+-excretion but elevated intestinal K+ secretion that resulted in less cumulated K+ in NS. Aldosterone was suppressed at day 8. The NS-associated changes in intestinal, but not renal, K+ handling responded to suppression of corticosterone, while ATI and MR blockers and amiloride had no effect on urine K+ excretion during NS. In PA...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research