Five-Year Follow-up of a Severe Case of Pertussis in Oregon, 2012.

We describe the medical course and sequelae of an infant's severe pertussis illness through age 5½ years. The child has failed to meet developmental milestones, requires substantial medical care, and bears the burdens of chronic lung disease, stroke, epilepsy, impaired neurodevelopment, and problems with vision. The medical and social burden of pertussis among infants too young to be vaccinated underscores the importance of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccination during pregnancy. PMID: 31568732 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

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We present a young female patient (36 years) admitted to Department of Ophthalmology due to visual loss on the left eye. Magnetic resonance imaging showed demyelinating lesions in frontal and parietal lobe, periventricularly, in mesencephalon and right cerebellar hemisphere, and left optic neuritis; magnetic resonance angiography was normal. The patient's history revealed renal dysfunction, hypothyroidism, and miscarriage in the 6th month of pregnancy due to eclampsia, and Fabry disease in family (mother and two sisters). She was transferred to the Department of Neurology for further evaluation of the demyelinating disorde...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
We present here one of the first cases of virological failure in real world during treatment with bictegravir/emtricitabine/tenofovir alafenamide (Biktarvy®). On March 2019, an antiretroviral-experienced HIV-infected patient was admitted to hospital because of cerebral toxoplasmosis. After undergoing treatment with sulfadiazine-pyrimethamine for two weeks, the patient initiated a Biktarvy® treatment, with 6.01 HIV RNA Log copies/mL, and 37 CD4 cells/μL. After two months under antiretroviral therapy (ART), acute neurologic deterioration with epilepsy, right hemiparesis and dysphagia occurred, leading to nasogastr...
Source: Antiviral Therapy - Category: Virology Source Type: research
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Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
Conclusion: These findings suggest that the epilepsy group showed reduced cognitive scores even though they did not suffer from frequent seizures and were not drug-resistant. PMID: 31971099 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
The Gaithersburg biotech's latest move reflects its fundamental strategy: Watch for opportunities to address a virus outbreak.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) a...
Source: Peptides - Category: Biochemistry Source Type: research
This study was done in a newly available large-scale claims database, which may differ from other population databases, by it size and exhaustiveness•The methods elaborate on standard high-dimensional propensity scores as adapted to this claims databaseGraphical abstract
Source: MethodsX - Category: Science Source Type: research
Publication date: Available online 23 January 2020Source: Reproductive BioMedicine OnlineAuthor(s): Ryan D. Rose, Michael F. Barry, Emma V. Dunstan, Siu Man Yuen, Lyndal P. Cameron, Emma J. Knight, Robert J. Norman, Mary-Louise HullAbstractResearch QuestionDoes Embryogen®/BlastGen™ culture medium improve live birth rates compared to standard culture medium for women undergoing IVF/ICSI with poor prognosis.DesignRandomised clinical trial. 100 couples undergoing IVF/ICSI, were randomly allocated to having their inseminated oocytes incubated in either Embryogen®/BlastGen™ sequential culture media (Cooper S...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
This study was illustrating that Piperine loaded CuQDs@HA/PLGA nanostructures exhibit improved neuroprotection and encourage the activation of astrocytes in chemical kindling model of epilepsy. This proposed material could be a novel and effective therapeutic platform for the targeted drug delivery systems.Graphical Abstract
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Companies aim to have vaccine in production within 16 weeks before entering testing stageThere are no vaccines or treatments approved for the new coronavirus, but the race is on to develop one.This week the Coalition for Epidemic Preparedness Innovations (Cepi)announced it would commit $11m ( £8.4m) to three programmes led by the companies Inovio Pharmaceuticals, Moderna and the University of Queensland.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Science China World news Asia Pacific Medical research Vaccines and immunisation Health Source Type: news
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