Rethinking Prenatal Exercise Trials: How Can We Improve Translation?

Regular exercise is important to maintain health and reduce the risk of chronic disease in the general population. The greatest health benefits occur in sedentary individuals who incorporate small amounts of activity into their daily routine. Additional benefits of exercise for pregnant women include reduced rates of maternal and fetal complications, such as pre-eclampsia, gestational hypertension, gestational diabetes, Caesarean section, excessive gestational weight gain, and macrosomia.1 The trial of supervised moderate to vigorous prenatal exercise by Mireia Pelaez and colleagues,2 published in this issue of Mayo Clinic Proceedings, adds to this body of evidence.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research

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Publication date: December 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 8Author(s): Alexandra Pouliot, Riham Elmahboubi, Catherine AdamAbstractObjectivesAt 1 Canadian university hospital, pregnant women were routinely screened for gestational diabetes mellitus (GDM) with a 75-g oral glucose tolerance test (OGTT). Diagnostic plasma glucose thresholds were as follows: fasting: ≥5.3 mmol/L, 1 h: ≥10.6 mmol/L and 2 h: ≥9.0 mmol/L. In 2015, diagnostic thresholds were reduced to those recommended by the International Association of Diabetes in Pregnancy Study Group (IADPSG) as follows: fasting: ≥5.1 mmo...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionBreech presentation in preterm labor is associated with obstetric risk factors compared to cephalic presentation. These risks decrease linearly with the gestational age. In moderate to late preterm delivery, breech presentation is a high-risk state and some obstetric risk factors are yet visible in early preterm delivery. Breech presentation in extremely preterm deliveries has, with the exception of preterm premature rupture of membranes, similar clinical risk profiles as in cephalic presentation.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
This study aims to determine the incidence of pre-eclampsia and distribution of risk factors of pre-eclampsia at Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal. A retrospective study included 4820 pregnant women from 17 September to 18 December 2017. Data were obtained from the medical records of the hospital’s Statistics Department. Associations between the risk factors and pre-eclampsia were determined using logistic regression analysis and expressed as odds ratios. The incidence rate of pre-eclampsia in the study population was 1.8%. Higher incidence of pre-eclampsia was observed for wome...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Objectives: Either maternal gestational diabetes mellitus (GDM) or hypertensive disorder of pregnancy (HDP) is associated with an increased risk of obesity in the offspring. However, their joint associations with obesity in offspring remain unclear. We investigated the joint associations of maternal GDM and HDP with childhood overweight in offspring.Methods: We performed a large study in 1967 mother-child pairs. Maternal GDM was diagnosed according to the 1999 World Health Organization (WHO) criteria. HDP was defined as self-reported doctor-diagnosed hypertension or treatment of hypertension (including gestational hyperten...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal women worldwide and is characterized by reproductive, endocrine, and metabolic abnormalities. The clinical manifestations of PCOS include oligomenorrhea or amenorrhea, hyperandrogenism, ovarian polycystic changes, and infertility. Women with PCOS are at an increased risk of suffering from type 2 diabetes; me\tabolic syndrome; cardiovascular events, such as hypertension, dyslipidemia; gynecological diseases, including infertility, endometrial dysplasia, endometrial cancer, and ovarian malignant tumors; pregnancy complication...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Background: Women who experience complications of pregnancy including pre-eclampsia, hypertension and diabetes are at increased risk of coronary artery disease (CAD). Yet patients and their medical providers have low awareness of the significance of ‘non-traditional’ cardiovascular risk factors. We aimed to determine the prevalence and awareness of pregnancy-related vascular complications in women with known CAD.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 673 Source Type: research
CONCLUSIONS: Two new studies (406 women) have been incorporated to one of the comparisons for this update. Although the evidence suggests that CGM in comparison to intermittent glucose monitoring may reduce hypertensive disorders of pregnancy, this did not translate into a clear reduction for pre-eclampsia, and so this result should be viewed with caution. No differences were observed for other primary outcomes for this comparison. The evidence base for the effectiveness of other monitoring techniques analysed in the other five comparisons is weak and based on mainly single studies with very low-quality evidence. Additiona...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Bianca Cox1†, Maria Tsamou1†, Karen Vrijens1, Kristof Y. Neven1, Ellen Winckelmans1, Theo M. de Kok2, Michelle Plusquin1 and Tim S. Nawrot1,3* 1Center for Environmental Sciences, Hasselt University, Hasselt, Belgium 2Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands 3Department of Public Health, Environment and Health Unit, Leuven University (KU Leuven), Leuven, Belgium Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and later-life health of the newborn, yet the implicated molecular mechanisms remain largely unknown. As the master reg...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsBariatric surgery is a successful treatment of maternal obesity, but certain surgery-specific risks may exist. More data are needed to determine clinical guidelines. The long-term effects of surgery on pregnancy outcomes are unknown.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Marjon E. Feenstra1†, Mirthe H. Schoots2†, Torsten Plösch1, Jelmer R. Prins1, Sicco A. Scherjon1, Albertus Timmer2, Harry van Goor2 and Sanne J. Gordijn1* 1Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Objective: Management of late fetal growth restriction (FGR) is limited to adequate fetal monitoring and optimal timing of delivery. The Disproportionate Intrauterine Growth Intervention ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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