Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial

Publication date: Available online 30 September 2019Source: The Lancet Respiratory MedicineAuthor(s): Richard T Davey, Eduardo Fernández-Cruz, Norman Markowitz, Sarah Pett, Abdel G Babiker, Deborah Wentworth, Surender Khurana, Nicole Engen, Fred Gordin, Mamta K Jain, Virginia Kan, Mark N Polizzotto, Paul Riska, Kiat Ruxrungtham, Zelalem Temesgen, Jens Lundgren, John H Beigel, H Clifford Lane, James D Neaton, Richard T DaveySummaryBackgroundSince the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (hIVIG) might have clinical benefit for patients with influenza infection, but definitive data do not exist. We aimed to evaluate the safety and efficacy of hIVIG in a randomised controlled trial.MethodsThis randomised, double-blind, placebo-controlled trial was planned for 45 hospitals in Argentina, Australia, Denmark, Greece, Mexico, Spain, Thailand, UK, and the USA over five influenza seasons from 2013–14 to 2017–18. Adults (≥18 years of age) were admitted for hospital treatment with laboratory-confirmed influenza A or B infection and were randomly assigned (1:1) to receive standard care plus either a single 500-mL infusion of high-titre hIVIG (0·25 g/kg bodyweight, 24·75 g maximum; hIVIG group) or saline placebo (placebo group). Eligible patients had a National Early Warning score of 2 points or greater at the time of scree...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research

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Publication date: Available online 16 November 2019Source: Journal of Contextual Behavioral ScienceAuthor(s): Lidia Cobos-Sánchez, Juan M. Flujas-Contreras, Inmaculada GómezAbstractPsychological flexibility refers to the ability to be in contact with emotions, thoughts and feelings while behavior is directed at values. Psychological flexibility is considered to be a protective factor of health and psychological wellbeing, and includes six interrelated factors including; acceptance, values, committed action, contact with the present moment, self as context and defusion. The aim of this study is to assess the p...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
ConclusionThese data indicate that KPC-producing polyclonal K. pneumoniae are frequent causes of nosocomial hospital outbreaks in South America. Similar genotypes have been reported in Colombia, Argentina, Brazil, North America and Asia.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionWithin the limitations of the study, GBR with or without autogenous block graft may be an effective approach in augmenting horizontally deficient mandibular or maxillary ridges, before the placement of dental implants. However, more complications may be seen with the use of an autogenous block graft related to the donor sites.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
ConclusionsThe authors concluded that oral health interventions focusing on indigenous populations have shown mixed results regarding improvements in oral health and other related outcomes.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. PMID: 31730677 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
During influenza pandemics, pregnant women are at high risk of influenza-associated severe disease. High rates of secondary bacterial pneumonia and a higher case fatality rate than the general population have been documented among pregnant women during the 1918-19 and 1957-58 influenza pandemics (1 –3). A pooled international analysis conducted during the 2009 H1N1 influenza A pandemic has shown that pregnant women – mainly in the third trimester – suffered a higher incidence of hospitalization than non-pregnant women of childbearing age (4).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
A recent article and accompanying commentary in the journal Pediatrics describe what we currently know about children who have died from influenza over the past decade or more. The Centers for Disease Control (CDC) has collected information about this since the 2003-2004 influenza season. In that first report, there were 153 deaths. Since then there have been at least 100 influenza deaths annually among children. Several characteristics have not changed. About half of the deaths occur in children who were otherwise normal; that is, they had no underlying chronic condition that would predispose...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Infectious Disease Pediatrics Source Type: blogs
Conclusion This modelling study shows how the strains of influenza A – "bird flu" – circulating when a person is born give them lifelong protection against new subtypes with the same H protein groups. The researchers call this immune imprinting. This may help to explain the high severity and mortality rate seen among certain groups. For example, the massive flu pandemic of 1918 was an H1N1 strain. This had a very high fatality rate among young adults, which the researchers consider may have been because when they were born (between 1880 and 1900), H3 was the dominant strain. Therefore they had no prot...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news
Discussion We applied simple phenomenological models applied to surveillance data of Zika cases from Antioquia, Colombia, to forecast the size of the Zika epidemic and evaluate the reproduction number within the first two disease generations. Using the GRM model that incorporates the possibility of sub-exponential growth dynamics22, we were able to generate reasonable forecasts of epidemic size within 22% of observed values based on 30 days of epidemic data. By contrast, the logistic growth model consistently underestimated the epidemic size and was not able to capture the early growth phase of the Zika epidemic, which exh...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
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