3-Dimensional regional and global strain abnormalities in hypertrophic cardiomyopathy

This study evaluated 3D principal and conventional strain characteristics of non-enhanced myocardium in patients with HCM. 3D principal and conventional strain analysis was conducted in 51 HCM patients and 38 healthy controls. Principal strain was reduced within the non-enhanced myocardium of HCM as compared with controls (maximum principal: 51.5 ± 23.7 vs. 75.1 ± 21.4%, P< 0.0001; minimum principal: − 18.4 ± 4.0 vs. − 20.1 ± 2.9%, P< 0.05). Principal strain within the non-enhanced myocardium was incrementally reduced in HCM patients with extensive global LGE ( ≥ 15%) (maximum principal: 41.6 ± 17.5 vs. 56.9 ± 25.9%, P< 0.05; minimum principal: − 16.9 ± 3.9 vs. − 19.1 ± 4.0%, P = 0.1), as was longitudinal ( − 10.5 ± 2.6 vs. − 12.7 ± 2.6%, P< 0.05) and circumferential strain ( − 11.0 ± 2.7 vs. − 14.0 ± 2.9%, P< 0.01). Principal strain within non-enhanced myocardium was significantly correlated with indexed LV mass (P< 0.0001), maximum (P = 0.0008), and mean wall thickness (P< 0.0001), but not LGE (P = 0.0841). In adjusted analysis, all strain measures within non-enhanced myocardium were independently associated with indexed LV mass (maximum principal: P = 0.0003; minimum principal: P = 0.0039; longitudinal: P = 0.0015; circumferential: P = 0.0002; radial: P = 0.0023). 3D principal strain of non-enhanced myocardium was significantly reduced in HCM patients as compared with controls, and was incrementally reduced among patients ...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research