Cancers, Vol. 11, Pages 1407: Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression
In conclusion, our data indicate that hepatic pro-survival UPR signaling suppresses the liver-specific HNF4A and its downstream target miR-122 in cirrhosis. These results provide an explanation as to why cirrhosis is a risk factor for the development of HCC in chronic HCV infection.
Source: Cancers - Category: Cancer & Oncology Authors: Yucel Aydin Ramazan Kurt Kyoungsub Song Dong Lin Hanadi Osman Brady Youngquist John W. Scott Nathan J. Shores Paul Thevenot Ari Cohen Srikanta Dash Tags: Article Source Type: research
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