Cancers, Vol. 11, Pages 1463: Risk of Hematologic Malignant Neoplasms after Postoperative Treatment of Breast Cancer

This study aimed to analyze the role of postoperative treatment for BC in the development of subsequent HM. Using the French National Health Data System, we examined the HM risks in patients diagnosed with an incident primary breast cancer between 2007 and 2015, who underwent surgery as first-line treatment for BC. Main outcomes were acute myeloid leukemia (AML), Myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), multiple myeloma (MM), Hodgkin’s lymphoma or non-Hodgkin’s lymphoma (HL/NHL), and acute lymphoblastic leukemia or lymphocytic lymphoma (ALL/LL). Analyses were censored at HM occurrence, death, loss to follow up, or December 2017. The risk of each type of HM was compared according to the initial postoperative treatment of breast cancer. Of a total of 324,056 BC survivors, 15.5% underwent surgery only, 46.7% received radiotherapy after surgery, 4.3% received chemotherapy after surgery, and 33.5% received all three modalities. Overall, 2236 cases of hematologic malignancies occurred. Compared to the surgery alone group, AML was significantly increased after surgery plus radiation (aHR, 1.5; 95% CI, 1.0–2.1), surgery plus chemotherapy (aHR, 2.1; 95% CI, 1.2–3.6) and all modalities (aHR, 3.3; 95% CI, 2.3–4.7). MDS was significantly increased after surgery plus chemotherapy (aHR, 1.7; 95% CI, 1.1–2.5) or after all modalities (aHR, 1.4; 95% CI, 1.1–1.8). HL/NHL were significantly increas...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research

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Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
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Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
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Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
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