543PThe impact of completeness of chemotherapy on the efficacy of irinotecan in the preoperative chemoradiotherapy of (CRT) locally advanced rectal cancer

ConclusionsOur analysis suggested a higher completeness of weekly irinotecan was associated with a higher CR rate. Comprehensive evaluation of the patient performance is necessary before starting the intensified treatment.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research

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CONCLUSION: Symptom duration is not associated with localization, nor is the tumor stage. Diagnosis of colorectal cancer at an earlier stage may be best achieved by screening of the population. PMID: 31418412 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Tags: Turk J Gastroenterol Source Type: research
Conclusions: XELOXIRI is a feasible and active regimen for patients with locally advanced rectal cancer. Febrile neutropenia was the DLT, and the RD of irinotecan is 150 mg/m2.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: XELOXIRI is a feasible and active regimen for patients with locally advanced rectal cancer. Febrile neutropenia was the DLT, and the RD of irinotecan is 150 mg/m2. PMID: 31266024 [PubMed - as supplied by publisher]
Source: Oncology - Category: Cancer & Oncology Authors: Tags: Oncology Source Type: research
BACKGROUND: There is still controversy about the relationship between preoperative anemia and outcomes after rectal cancer surgery. OBJECTIVE: The aim of this study was to analyze the association between preoperative anemia and postoperative complications and the survival of patients undergoing surgery for rectal cancer in the era of laparoscopic surgery and modern perioperative care. DESIGN: This was a cohort study. SETTINGS: Data were gathered from 71 hospitals in The Netherlands. PATIENTS: Patients who underwent resection for rectal cancer in 2011, for whom preoperative hemoglobin level was registered, wer...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contribution: Colorectal Cancer Source Type: research
ConclusionThis is one of the largest studies to date to describe the epidemiology of EoCRC in USA. We found EoCRC to occur predominantly in the Caucasian and female population. EoCRC presented more frequently with left-sided and rectal CRC. We also identified signs/symptoms as well as comorbidities associated with EoCRC. Patients with these features may benefit from earlier screening.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Yikan Cheng1†, Yan Ma1†, Jian Zheng1†, Hua Deng2†, Xueqin Wang3,4, Yewei Li3,4, Xiaolin Pang1, Haiyang Chen1, Fang He1, Lei Wang5*, Jianping Wang5* and Xiangbo Wan1* 1Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Department of Radiation Oncology, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 2Department of Radiation Oncology, Banner-University Medical Center Phoenix, Phoenix, AZ, United States 3Department of Statistical Science, Southern China Center for Statistical Science, School of Mathe...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 March 2019Source: European Journal of Surgical OncologyAuthor(s): Gaya Spolverato, Nicola Gennaro, Manuel Zorzi, Massimo Rugge, Claudia Mescoli, Mario Saugo, Maria Chiara Corti, Salvatore PucciarelliAbstractIntroductionFailure to rescue (FTR) patients from postoperative complications could contribute to the variability in surgical mortality seen among hospitals with different volumes. We sought to examine the impact of complications and FTR on mortality following rectal surgery.MethodsThe National Italian Hospital Discharge Dataset allowed identifying 75,280 patients who underwent rect...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusion: The need for public awareness about diabetes as an important risk factor of CRC is necessary. Public seminars, school visits and social media will have important role in educating the public with regards to symptoms and diagnostic procedures of CRC. PMID: 30255699 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions: POA was an independent risk factor for incisional surgical site infection after colorectal resection for CRC, and correcting POA should be considered before elective surgery. PMID: 29853859 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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