1682PHealth-related quality of life issues of patients affected by desmoid-type fibromatosis: Experiences from two countries

ConclusionsPatients affected by DTF experience psychological issues regarding the unpredictable tumour growth behaviour. Validation in a large international cohort is needed to devise a HRQL-questionnaire specific to DTF patients to fully address their needs.Legal entity responsible for the studyThe authors.FundingStichting Coolsingel Rotterdam.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research

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AbstractCowden's syndrome (CS) is a rare autosomal dominant, hereditary multiorgan disease with higher risk for malignancies (breast, thyroid, endometrium). Mucocutaneous lesions occur in 90% of cases and are characterized by facial trichilemmomas,  oral mucosal papillomas and benign acral keratoses. A case of 39-year-old female patient with a chief complaint of " white spots " on the upper and lower attached gingiva accompanyed with skin changes on the face, hands and soles is presented. Her family medical history revealed that her mother had endometrial polyp and sister thyroid cancer. In her medical ...
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research
Desmoid ‐type fibromatosis following thoracotomy is rare and has been previously reported only in
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CLINICAL IMAGE Source Type: research
Abstract Pseudo-Meigs syndrome is defined as the secondary accumulation of ascites and hydrothorax associated with pelvic tumor other than benign ovarian tumor such as fibroma, which classically resolve upon surgical removal of the tumor. Here we report a case of pseudo-Meigs syndrome caused by a giant uterine leiomyoma, which was initially suspected to be ovarian cancer. A 37-year old nulliparous woman presented with a 5-month history of abdominal distension and anorexia. Abdominal ultrasonography revealed the presence of a giant cystic lesion and solid mass in the peritoneal cavity along with a massive ascites. ...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
Analyze for the first time the immunohistochemical expression in tooth germ (TG) ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF) and ameloblastic fibrosarcoma (AFS) of fatty acid synthase (fasn) and cyclooxygenase (cox-2), which are highly associated to tumorigenic events and poor prognosis in several types of cancer and also are promising chemotherapy targets.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Abstract We summarize here available data about systemic treatments of desmoids tumors, as well in adult patients as pediatric patients. Until 2018, the level of evidence associated with these treatments (NSAI, hormonal therapies, tyrosine kinase inhibitors, chemotherapy) was very low, based on retrospective studies or non-randomized phase 2 trials with limited number of cases. In 2018-2019, 2 large randomized trials have been published, including one large superiority phase 3 trial comparing sorafenib to placebo. This trial clearly demonstrates the clinical benefit of sorafenib over placebo (level of evidence IA)...
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research
The resection of distal airways obstructing tumours is a traditional indication of therapeutic bronchoscopy. Lung cancer is the most frequent cause of the obstruction. Takeout procedures of the benign tumours, endobronchial carcinoids and endobronchial metastases are considerably less frequent. These tumours can be removed completely, some of them definitively. Present work analyses experience with these tumours in one tertiary bronchological centre. During the period from 1993 to 2018, 29.121 bronchoscopies were performed and 124 benign tumours, 19 typical carcinoids (G1 NET) and 35 endobronchial metastases were removed. ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
Authors: Abdulrahman Jnr GO, Das N, Lutchman Singh K Abstract Ovarian cancer is a lethal gynecological malignancy. Although CA-125 is commonly measured in women with adnexal mass, it is estimated that it only has a positive predictive value (PPV) of 69% and a negative predictive value (NPV) of 88% for the detection of ovarian cancer. The aim of this study was to investigate the diagnostic significance and predictive impact of thrombocytosis in women with suspected or confirmed ovarian cancer. This was a retrospective study of women who had surgery for adnexal mass over a 48-month period between September 2014 and S...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Metaplastic breast carcinoma (MPBC) represents 0.2-5% of all breast cancers and is typically very aggressive, with worse clinical outcomes than triple negative invasive breast cancers (TNBC)[1,2]. It is comprised of ductal, squamous, and/or chondroid, and spindle elements, with squamous cell carcinoma being the most frequent histological subtype. The World Health Organization (WHO) further divides metaplastic breast cancer into several subgroups: low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, squamous cell carcinoma, spindle cell carcinoma, metaplastic carcinoma with mesenchymal differentiation...
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research
We report a case of PTC-DTF with infiltration of the mesenchymal component of tumor into perithyroidal muscle and early recurrence of desmoid after thyroidectomy, an outcome previously not reported.Presentation of caseA 20-year-old man underwent left hemithyroidectomy for a thyroid nodule. Pathology demonstrated a 4.2 cm tumor with PTC-DTF with the PTC comprising
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Rationale: Ossifying fibroma is benign fibro-osseous neoplasm. The authors report a case of ossifying fibroma in the mandibular angle suspected as metastasis of clear cell renal cell carcinoma. Patient concerns: A 74-year-old man presented to the primary hospital complaining of frequent urination. A tumor in the left kidney was detected via an abdominal computed tomography scan. The patient then visited the Department of Urology at our hospital. Diagnoses: According to whole-body imaging examinations, the patient was suspected of having renal cancer with mandibular metastasis. Also, a cystic lesion of the maxilla w...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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