81PSIPA1 is a modulator of HGF induced tumour metastasis via the regulation of tight junctions in lung adenocarcinoma cells

ConclusionsSIPA1 may act as a targeting molecule and a marker for prognosis in lung adenocarcinoma. It has an effect on pathways associated with aggressive behavior and barrier function in lung cancer cells. HGF induced malignant behavior of cancer cells requires the presence and influence of SIPA1, which can effect changes in cancer cell behavior by interacting with the TJ complex.Legal entity responsible for the studyTracey A. Martin - Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research