MGMT immunohistochemistry in pituitary tumors: controversies with clinical implications

ConclusionsThese findings could explain lack of response to TMZ treatment in patients with false negative MGMT immunohistochemistry. Evaluation of tumor samples for MGMT expression should carefully be carried-out using the optimum immunohistochemical protocol to obtain consistent and reliable results that help to identify patients that could respond to TMZ therapy.
Source: Pituitary - Category: Endocrinology Source Type: research