Rules keep girl from transplant
10-year-old denied lung transplant because of her age - CNN's Susan Candiotti Reports
AbstractIntroductionFlexible fiberoptic bronchoscopy (FFB) plays an important role in the surveillance of cystic fibrosis (CF) patients after lung transplantation (LTx). With rapid onset and clearance, propofol provides a safe and efficient method for sedation during FFB, yet sedation requirements for CF patients are not well described.ObjectivesDue to pharmacokinetic differences for other classes of drugs in CF patients, this study was performed to examine propofol requirements for sedation during bronchoscopy in lung transplant recipients with CF.MethodsA single-center retrospective cohort study was performed to examine ...
Claire Wineland vowed she wouldn't have a lung transplant, but her decline from cystic fibrosis made her reconsider. Now she's fighting for a chance at survival.
Mycophenolate mofetil (MMF) is commonly prescribed after transplantation and has important advantages over other immunosuppressive drugs but frequent gastrointestinal (GI) side effects limit its use. The mechanism(s) underlying MMF-related GI toxicity have yet to be elucidated.
ConclusionsEarly tracheostomy following lung transplantation decreased both intensive care and hospital stay, due to improved postoperative recovery, even in patients with poor preoperative conditions. Furthermore, length of hospital stay in patients with early tracheostomy was similar to that of patients without tracheostomy after lung transplantation.
A 67-year-old, non-Hispanic white male underwent bilateral lung transplantation in 2016 for idiopathic pulmonary fibrosis. The patient had good graft function after transplantation, with a peak forced expiratory volume in 1 second of 2.27 liters. Surveillance bronchoscopy and biopsies done at 1, 3, and 6 months post-transplantation did not show any evidence of acute rejection or infection. He was lost to follow-up until 15 months after transplantation, when he presented with 1 week of dyspnea, cough, and fever.
Ischemia-reperfusion injury, a form of sterile inflammation, is the leading risk factor for both short-term mortality following pulmonary transplantation and chronic lung allograft dysfunction. While it is well recognized that neutrophils are critical mediators of acute lung injury, processes that guide their entry into pulmonary tissue are not well understood. Here, we found that CCR2+ classical monocytes are necessary and sufficient for mediating extravasation of neutrophils into pulmonary tissue during ischemia-reperfusion injury following hilar clamping or lung transplantation. The classical monocytes were mobilized fr...
Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transpl...