Correlation of late gadolinium enhancement MRI and quantitative T2 measurement in cardiac sarcoidosis

PurposeTo investigate the potentially improved detection and quantification of cardiac involvement using novel late‐gadolinium‐enhancement (LGE) cardiac magnetic resonance imaging (MRI) and quantitative T2 measurement to achieve better myocardial tissue characterization in systemic sarcoidosis. Materials and MethodsTwenty‐eight patients with systemic sarcoidosis underwent a cardiac magnetic resonance imaging (CMR) study on a 1.5T system. Precontrast CMR included left ventricular (LV) and right ventricular (RV) function and quantitative T2 measurement. Postcontrast LGE‐MRI included inversion‐recovery fast‐gradient‐echo (IR‐FGRE) and multicontrast late‐enhancement imaging (MCLE). ResultsLV functional parameters were normal in all patients (LVEF = 61.2 ± 8.5%) including with cardiac involvement (LVEF = 59.4 ± 12.1%) and without (LVEF = 61.7 ± 7.5%) while the average RV function was comparatively decreased (RVEF = 48.0 ± 6.6%, P 
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research

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ConclusionsThis case report will help physicians suspect probable NMOSD in patients having recurrent, multiple cranial neuropathies, and provide them appropriate management and care.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Case Report Source Type: research
Rationale: Neurological complications of varicella-zoster virus (VZV) infection include cerebral infarction, meningoencephalitis, segmental sensory disturbance, facial nerve palsy, and myelitis. Chronic myelitis is rarely reported. Diagnosis of VZV infection can be confirmed by elevated anti-VZV immunoglobulin G (IgG) antibody or detection of VZV DNA in the cerebrospinal fluid (CSF), the former reported to be superior. The detection rate of VZV DNA is generally thought to decrease with time after the onset of the condition. The utility of VZV DNA polymerase chain reaction (PCR) is thus thought to be limited to the acute ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Authors: Ha FJ, Agarwal S, Tweed K, Palmer SC, Adams HS, Thillai M, Williams L Abstract Cardiac sarcoidosis (CS) represents a unique diagnostic dilemma. Guidelines have been recently revised to reflect the increasingly established role of sophisticated imaging techniques. Trans-thoracic echocardiography (TTE) is widely adopted for initial screening of CS. Contemporary TTE techniques could enhance detection of subclinical LV dysfunction, particularly left ventricular (LV) global longitudinal strain assessment which predicts event-free survival (meta-analysis of 5 studies, hazard ratio 1.28, 95% confidence interval 1...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
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Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: EDITORIAL – INVITED Source Type: research
ABSTRACTBACKGROUNDPatients with cardiac sarcoidosis (CS) may present with arrhythmic events (AE): atrioventricular block (AVB) and/ or ventricular arrhythmias (VA). We sought to: 1.) Use regional analysis of cardiac magnetic resonance imaging (CMR) to describe anatomic and functional phenotypes of patients with CS and AE; 2.) Assess the association of regional CMR abnormalities with the combined endpoint of death, heart transplantation (HT) and AE; and 3.) Use machine learning (ML) to predict the combined endpoint based on CMR features. METHODS: We included 76 patients with CS and CMR. We analyzed cine images to determine ...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
Conclusion: Ophthalmologists should know that patient followed up with sarcoid uveitis can develop a primary vitreoretinal diffuse large B-cell lymphoma. PMID: 31268740 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Abstract BACKGROUND: Although recent reports showed that left ventricular ejection fraction (LVEF) is a prognostic factor in patients with cardiac sarcoidosis (CS), advances in diagnostic imaging have enabled us to detect CS patients with preserved LVEF in the early stage of the disorder. In the present study, we examined the prognosis and risk stratification in CS patients with preserved LVEF. METHODS AND RESULTS: We retrospectively examined 91 consecutive CS patients at our hospital from October 1998 to December 2015 (age, 57±11 years; male/female, 25/66) for the relationship between LVEF and major a...
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
Background: Current diagnostic criteria for cardiac sarcoidosis (CS) require histological confirmation from either cardiac or extracardiac specimens. Cardiac magnetic resonance imaging (CMR) and F18-fluorodeoxyglucose positron emission tomography (FDG-PET) are increasingly used to facilitate a non-invasive diagnosis of CS. We sought to compare CMR and cardiac PET findings in patients with suspected CS.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 069 Source Type: research
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Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
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