Mediating role of bone marrow lesion, synovitis, pain sensitization, and depressive symptoms on knee pain improvement following substantial weight loss

AbstractObjectiveMassive weight loss leads to marked knee pain reduction in persons with knee pain, but the reason for the reduction in pain is unknown. To quantify the contribution of MRI changes in pain sensitive structures, bone marrow lesions (BML), synovitis, and in pain sensitization, or depressive symptoms to knee pain improvement after substantial weight loss.MethodsMorbidly obese patients with knee pain on most days were evaluated before bariatric surgery or medical weight management and at 1 ‐year follow‐up for BML and synovitis seen on MRI, pressure pain threshold (PPT) at patella and right wrist, depressive symptoms (using CES‐D), and WOMAC pain survey. Natural effects models quantified the extent that achieving minimal clinically important difference (MCID) of ≥18% on the WOM AC pain scale could be mediated by weight loss‐induced changes in BML, synovitis, PPT, and depressive symptoms.ResultsOf 75 participants, 53.3% lost ≥20% weight by 1‐year; of these, 75% attained an MCID for pain improvement, compared with 34.3% in those who had
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research

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Authors: Hawker GA Abstract Osteoarthritis (OA) is the most common form of arthritis, affecting 1 in 3 people over age 65 and women more so than men. The prevalence of OA is rising due, in part, to the increasing prevalence of OA risk factors, including obesity, physical inactivity, and joint injury. OA-related joint pain causes functional limitations, poor sleep, fatigue, depressed mood and loss of independence. Compared to age and sex-matched peers, OA patients incur higher out of pocket health-related expenditures and substantial costs due to lost productivity. Most people with OA (59-87%) have at least one othe...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
By just engaging in the basic strategies in the Wheat Belly Total Health, Wheat Belly 10-Day Grain Detox, or Undoctored programs, many mild cases of small intestinal bacterial overgrowth, SIBO, reverse. These efforts thereby restore your ability to ingest prebiotic fibers without diarrhea, bloating, gas, abdominal discomfort, joint pain, and dark emotional feelings. Many people thereby are relieved of irritable bowel syndrome symptoms, fibromyalgia, or restless leg syndrome, or have greater power in reversing autoimmune conditions such as rheumatoid arthritis. Unfortunately, not everybody enjoys reversal of SIBO with our b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO grain-free probiotic undoctored wheat belly Source Type: blogs
Hongmei Zhu, Sha Nan, Chuanguang Suo, Qiulin Zhang, Manli Hu, Rong Chen, Juan Wan, Meng Li, Jianguo Chen and Mingxing Ding* College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Hypothalamic-pituitary-ovary (HPO) axis is a dominant system controlling ovulation during puberty. Electro-acupuncture (EA) has been widely used to cure the reproductive diseases associated with endocrinological disorders. However, whether EA treatment affects HPO axis activity of physiological animals and induces alterations on the hormones in the HPO axis was also unclear. Here, we performed the EA stimuli on bil...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The recent rise in opioid overdose deaths in the United States has been attributed to an increase in prescriptions written to patients for chronic pain. Patients with psoriasis have higher rates of comorbidities that may make them more likely to receive a prescription for an opioid, including psoriatic arthritis, obesity, anxiety and depression, but little is known about opioid prescribing practices in adults with psoriasis. We performed a cohort study using OptumInSight's electronic health records database to compare the rate of opioid prescriptions written to patients with psoriasis compared to adults without psoriasis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults. Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/ Cells are equipped with a protein disposal system in the form of the proteaso...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
When Paul Manafort appeared in court for sentencing recently, he was in a wheelchair and pleaded for leniency, in part because “his confinement had taken a toll on his physical and mental health.” He reportedly had symptoms of depression and anxiety — but what was the health problem that put him in a wheelchair? According to multiple news reports, the answer is gout. Yes, that ancient disease you may have thought didn’t exist anymore has stricken Mr. Manafort. He joins the rising number of people in the country diagnosed with this common disease. What is gout? Gout is a cause of severe joint pa...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Bones and joints Health Inflammation Source Type: blogs
This article will discuss a few factors that influence migraine (mostly episodic) and its treatment, such as sleep, obstructive sleep apnea (OSA), obesity, and affective disorders, as well as autoimmune diseases. Practitioners must be aware of these coexisting conditions (comorbidities) as they affect treatment. It is noted in literature that both the quantity (too much or too few hours) and the quality (OSA related) of sleep may worsen migraine frequency. An associated risk factor for OSA, obesity also increases migraine frequency in episodic migraine cases. A bidirectional relationship with migraine along with depression...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
ConclusionsOur findings support the importance of managing clusters of symptoms simultaneously, that is, collective symptom management. Inter ‐cluster dynamics between symptoms should be considered when nurses develop symptom management strategies or self‐management programs to improve the quality of life of rheumatoid arthritis patients.
Source: International Journal of Nursing Practice - Category: Nursing Authors: Tags: ORIGINAL RESEARCH PAPER Source Type: research
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