Risk-free mouth-swab DNA test reveals if surgery patients are at risk of scarring badly

French medical company BILHI Genetics has become the first to develop a first-of-its-kind test that, it says, is able to identify genes linked to a risk of keloid scars.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusion: The polymorphism of the NEDD4 gene rs8032158 could participate in the formation of keloids in the Egyptian population. The NEDD4 rs8032158 CC genotype may have a role in keloid severity. PMID: 32943899 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Hypertrophic scarring and keloid can cause significant emotional and physical discomfort. Cosmetic appearance, functional limitations, pain and pruritus form a degree of impairment. While the aetiology is not fully known, there is a wide array of treatment options which include excision, radiation, cryotherapy, silicone gel sheeting and intralesional injections. A relatively new modality is laser therapy. While results are promising, the number of different laser systems is substantial. This review evaluates the available evidence regarding outcomes on specific objective characteristics (i.e., erythema, pigmentation, heigh...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
Conditions:   Keloid;   Autologus Adipose Derived Stem Cells;   Feasibility;   Safety Intervention:   Biological: Autologous adipose derived stem cells Sponsor:   Makerere University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Keloid;   Autologus Adipose Derived Stem Cells;   Feasibility;   Safety Intervention:   Biological: Autologous adipose derived stem cells Sponsor:   Makerere University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Keloids can cause physical impairment and cosmetic disfigurement resulting in diminished quality of life. Excision for keloids is usually indicated after failure to respond to conservative therapy and may be combined with radiation therapy (RT) or injections of triamcinolone (TAC) or fluorouracil (5-FU).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
AbstractCommonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. Keloids are notoriously and particularly difficult to treat because of their tendency to recur after excision. The current standard of care is intralesional steroid (triamcinolone acetonide). However, because no therapy has yet proven to be fully curative, keloid treatments have expanded to include a number of options, from injections to multimodal approaches. This review details current treatment of keloids with injections (bleomycin, verapamil, hy...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
AbstractMost therapeutic approaches for keloids remain clinically unsatisfactory. In the last years, intralesional botulinum toxin-A (IL BTX-A) was proposed for treatment of keloids. Our aim of the study was to compare the clinical efficacy of IL BTX-A and IL 5-Fluorouracil (IL 5-FU) in treatment of keloids. A total of 50 patients with keloids were included in the study, 22 patients (with 26 keloids) were treated with IL BTX-A monthly for up to 6  months and other 22 patients (with 27 keloids) were treated with IL 5-FU weekly for up to 6 weeks, while the remaining 6 patients, each having multiple keloids, were tr...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Conclusion: The PR does not attract attention from the cosmetic point of view but many benign and malignant masses can be found in this region. Any masses detected in this area should be treated to prevent further growth.
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Brief Clinical Studies Source Type: research
Ocular adnexal aterio-venous malformations (AVMs) are rare congenital disabling anomalies, which may enlarge causing disfiguring deformity and rarely severe hemorrhage. These lesions are generally treated by preliminary endovascular embolization to shrink the arterio-venous malformation, followed by surgical gross total resection. The authors report a case of eyelid arterio-venous malformation in a 12-year-old girl, which progressively increased in size in few months. The patient complained mild itching, blurring of the vision, and mild tenderness. Magnetic resonance imaging showed an expansive mass with multiple arterial ...
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Case Reports Source Type: research
Nodular fasciitis (NF) is a rare and benign proliferation of fibroblasts and myofibroblasts that may be mistaken for a sarcoma due to clinically rapid growth, rich cellularity, and mitotic activity. A 14-year-old female was referred to the oral and maxillofacial surgery service with a nodular lesion in the tongue and 2 months ’ of evolution. Oral examination revealed a pedunculated nodule, 1.5 cm, pinkish, and irregular surface in the posterior tongue region. An excisional biopsy was performed, and the histopathologic analysis showed a proliferation of spindle cells arranged in fascicles, surrounded by dense connecti...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: 20190032 Source Type: research
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