Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α2-adrenoceptor antagonist vatinoxan hydrochloride.

CONCLUSIONS AND CLINICAL RELEVANCE: Atipamezole failed to restore heart rate and cardiac index in medetomidine-sedated dogs, and relapses into sedation were observed. Coadministration of vatinoxan with MED helped to maintain hemodynamic function and hastened the recovery from sedation after AA in dogs. PMID: 31556714 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31556714?dopt=Abstract

Source: American Journal of Veterinary Research - September 28, 2019 Category: Veterinary Research Authors: Turunen H, Raekallio MR, Honkavaara JM, Restitutti F, Kallio-Kujala IJ, Adam M, Nevanperä K, Scheinin M, Männikkö SK, Hautajärvi HJ, Larenza Menzies P, Vainio OM Tags: Am J Vet Res Source Type: research