Conservative vs Aggressive Treatment in Older Prostate Cancer Patients

Survival data of prostate cancer patients 70 and older show that those with three or more comorbidities and low- or intermediate-risk prostate cancer are less likely to die from prostate cancer than another health issue. But those with aggressive, high-risk disease are more likely to die from their prostate cancer.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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ConclusionsePLND is more likely to predict undetectable PSA at third month after radical prostatectomy, irrespective of disease characteristics.ResumenObjetivosAnalizar la probabilidad de PSA indetectable (27 G L se incluyeron en el grupo PGLPa (percentil 75). El tiempo quirúrgico fue más largo para el grupo de DGLPa. Dieciséis pacientes (69.6%) tratados con DGLPa presentaron PSA indetectable tras la operación. En el análisis multivariable, la probabilidad de PSA indetectable a los 3 meses fue mayor en los pacientes tratados con DGLPa (HR = 5,18; IC 95% = 1.16–23.11; p...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
ConclusionsMen with mHNPC gain treatment benefit from ADT + AAP irrespective of risk stratification for “risk” or “volume”.Patient summaryCoadministration of abiraterone acetate and prednisolone with androgen deprivation therapy (ADT) is associated with prolonged overall survival and disease control, compared with ADT alone, in all men with metastatic disease starting hormone therapy for the first time.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 23 August 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Mingshi Chen, Caihong Yuan, Tianshu XuSummaryBackgroundIn recent years, some studies showed that inflammatory bowel disease (IBD) might be associated with an increased risk of prostate cancer (PC), whereas some other studies indicated that IBD was not associated with the increased risk of PC. In the present study, we aimed to conduct a systematic review and meta-analysis to evaluate the association of IBD and PC risk.MethodsWeb of Science and PubMed were systematically searched on for link of PC risk a...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Experts at Weill Cornell Medicine in New York are using gene editing tool CRISPR to alter a string of human genetic code which is known to increase the risk of developing some cancers.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We present a robot-assisted approach for transrectal ultrasound (TRUS) guided prostate biopsy. The robot is a hands-free probe manipulator that moves the probe with the same 4 DoF that are used manually. Software was developed for three-dimensional (3-D) imaging, biopsy planning, robot control, and navigation. Methods to minimize the deformation of the prostate caused by the probe at 3-D imaging and needle targeting were developed to reduce biopsy targeting errors. We also present a prostate coordinate system (PCS). The PCS helps defining a systematic biopsy plan without the need for prostate segmentation. Comprehensive te...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
A radiation therapy model that personalizes treatment based on patient genomics...Read more on AuntMinnie.comRelated Reading: ASTRO: Prostate RT works better than expected in black men LED device could predict skin damage from breast RT SABCS: RT complicates breast implant reconstruction FDA: Discontinue use of Multidata RT devices Shortened RT works for low-risk prostate cancer patients
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
CONCLUSIONS: The preliminary results of the present phase II trial, using HT for moderate hypofractionation in localized prostate cancer, are optimal. In fact, HT guaranteed an acceptable tolerability profile with low rates of GU and GI side effects and, more specifically, no acute severe adverse events were recorded. Long-term findings are warranted. PMID: 31432765 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
AbstractThe survival impact of adhering to current physical activity guidelines after prostate cancer diagnosis is unknown. We therefore emulated a target trial of guideline-based physical activity interventions and 10-year survival among US men with nonmetastatic prostate cancer. We used observational data on 2,299 men in the Health Professionals Follow-up Study who were diagnosed with nonmetastatic prostate cancer from 1998 to 2010 and were free of conditions that might have precluded participation at baseline (first postdiagnostic questionnaire). We estimated their survival under several guideline-based physical activit...
Source: American Journal of Epidemiology - Category: Epidemiology Source Type: research
ConclusionsThe biology of lncRNA is multifaceted, demonstrating a complex array of molecular and cellular functions. These studies reveal that lncRNAs are involved in every stage of PCa. Their clinical utility for diagnosis, prognosis, and prediction of PCa is well supported, but further evaluation for their therapeutic candidacy is needed. We provide a detailed resource and view inside the lncRNA landscape for other cancer biologists, oncologists, and clinicians.Patient summaryIn this study, we review current knowledge of the non–protein-coding genome in prostate cancer (PCa). We conclude that many of these regions ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
AbstractObjectivesThe aim of this study is to evaluate the association between total testosterone density (TTD), defined as the ratio of serum TT to prostate volume (PV), and high tumor load (HTL) in low-risk prostate cancer (PCA) patients who underwent radical prostatectomy.Materials and methodsTumor load was defined as the percentage of prostate volume invaded by cancer (PPI-PCA) in the surgical specimen. Pathologic features including tumor upgrading, upstaging or positive surgical margins in the specimen defined unfavorable disease (UD). PSA, TT, PSA density (PSAD), TTD, percentage of biopsy positive cores (BPC), PV and...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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