Circulating Tumor Cells and Transforming Growth Factor Beta in Resected Pancreatic Adenocarcinoma

Portal vein (PV) circulating tumor cells (CTCs) and elevated peripheral blood (PB) levels of biomarkers have been associated with poor outcomes in pancreatic ductal adenocarcinoma (PDAC). Although transforming growth factor-beta (TGF β) is associated with CTCs in breast cancer, there are limited data evaluating a comprehensive biomarker panel and CTCs in PDAC patients. The authors hypothesized that tumor progression biomarkers would be associated with PV CTCs.

Source: Journal of Surgical Research - June 2, 2019 Category: Surgery Authors: Diego Vicente, Andrew J. Lee, Carolyn S. Hall, Anthony Lucci, Jeffrey E. Lee, Michael P. Kim, Matthew H.G. Katz, Mark W. Hurd, Anirban Maitra, Andrew D. Rhim, MD, Ching-Wei D. Tzeng Tags: Gastrointestinal Source Type: research