A pragmatic approach to intravenous anaesthetics and electroencephalographic endpoints for the treatment of refractory and super-refractory status epilepticus in critical care
Status epilepticus is a common neurological emergency, with overall mortality around 20%. Over half of cases are first time presentations of seizures. The pathological process by which spontaneous seizures are generated arises from an imbalance in excitatory and inhibitory neuronal networks, which if unchecked, can result in alterations in intracellular signalling pathways and electrolyte shifts, which bring about changes in the blood brain barrier, neuronal cell death and eventually cerebral atrophy.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Lara Prisco, Mario Ganau, Sidra Aurangzeb, Olivia Moswela, Claire Hallett, Simon Raby, Karina Fitzgibbon, Christopher Kearns, Arjune Sen Tags: Review Source Type: research