Feds step in; girl fights for lungs

U.S. Health and Human Services Secretary Kathleen Sebelius asked the nation's transplant system Friday to review its lung allocation policy as a 10-year-old Pennsylvania girl in need of a lung fights for her life.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Cystic fibrosis liver disease (CFLD) remains the third leading cause of death in patients with cystic fibrosis. Although most patients with CFLD present in childhood, recent studies suggest a second wave of liver disease in adulthood. There are no clear guidelines for diagnosing CFLD. Treatment options for CFLD remain limited, and while UDCA is widely used, its long-term benefit is unclear. Those who develop hepatic decompensation or uncontrolled variceal bleeding may benefit from liver transplant, either alone, or in combination with lung transplant.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: Our results suggest that ESS is associated with a reduction in the frequency of antibiotic utilization for respiratory tract infections in lung transplant recipients with CF. A prospective study is needed to investigate these relationships further. PMID: 30781973 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
AbstractAimsPatients with heart failure (HF) are known to have a reduced pulmonary diffusion capacity for carbon monoxide (DLCO), but little is known about how lung function relates to central haemodynamics. The aim of this study was to investigate the association between haemodynamic variables and pulmonary diffusion capacity adjusted for alveolar volume in congestive HF patients and to analyse how predicted DLCO/VA affects mortality in relation to the haemodynamic status.Methods and resultsWe retrospectively studied right heart catheterization (RHC) and lung function data on 262 HF patients (mean age 51  ±&nb...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
We have read with great interest the case report by Pujol et al entitled Synchronous multiple non-small cell lung cancers in an allograft lung recipient [1], about a young cystic fibrosis lung transplant recipient who developed metastatic lung cancer. We would like to comment on this ‘rare’ long-term complication post lung transplantation. Recent registry data from the International Society of Heart and Lung Transplantation showed that the overall incidence of a malignancy post lung transplantation at 1, 5 and 10 years is 5.3%, 19.6% and 31.7% respectively [2] In observation al studies the incidence of lung can...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
This study aims to examine outcomes of patients who received ECMO as a bridge to lung transplantation.MethodsStatistical analysis was performed on data gathered retrospectively from the electronic medical records of adult patients who received ECMO as BTT at Columbia University Medical Center from April 2009 through July 2018.ResultsOne hundred and twenty-one adult patients were placed on ECMO as bridge to lung transplantation. Seventy (59%) patients were successfully bridged to lung transplantation. Simplified Acute Physiology Score II, unplanned endotracheal intubation, renal replacement therapy, and cerebrovascular acci...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Primary graft dysfunction (PGD) is the most important contributor to early morbidity and mortality in lung transplant recipients and reflects a combination of allograft ischemia-reperfusion injury, vasogenic pulmonary edema and inflammatory changes mediated by the innate immune system.1,2,3 Patients who develop PGD are at increased risk of poor lung function and death.4-6 There are limited therapeutic options available to patients who develop PGD after lung transplantation and as such, the main focus has been on the identification of risk factors for PGD and prevention strategies.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Mechanical circulatory support devices, i.e., Left Ventricular Assist Devices (LVADs), are increasingly utilized for hemodynamic restoration in patients with advanced and end-stage heart failure.1 The latest generation of miniaturized, continuous-flow LVADs has afforded enhanced patient survival and quality of life compared to earlier pulsatile pneumatic systems, and is now approved for both bridge-to-transplant as well as for definitive destination therapy.1 Despite clinical efficacy of these devices, LVAD thrombosis, either in the form of pump thrombosis or as thromboembolic events, remains a common and vexing complicati...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Publication date: Available online 16 February 2019Source: Social Science &MedicineAuthor(s): Athena EngmanAbstractThe concept of biographical disruption has now enjoyed nearly 40 years of use in medical sociology. This paper argues that taking an embodied approach to biographical disruption helps to explain the concept's enduring efficacy. Drawing on the work of Maurice Merleau-Ponty and contemporary theories of embodiment inspired by his phenomenology, this paper advances that biographical disruption involves, in the first instance, a disruption to the ability to enact an embodied orientation towards the world. Biogr...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
In this report, early graft dysfunction was diagnosed at day 3 and the patient was empirically treated with antibiotics and high dose corticosteroid therapy. Death occurred on the 29th post-operative day and an autopsy revealed abundance of foamy macrophages in lung tissue consistent with ASMD cells.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: LETTER TO THE EDITOR Source Type: research
Professor Francis Fontan, the pioneer in the field of congenital heart surgery and former president of the European Association for Cardio-Thoracic Surgery, recently passed away in January 2018. The ‘Fontan operation’,1 the final stage in a series of cardiac repairs for children with single ventricle anatomy, saved the lives of numerous children and is undoubtedly one of the greatest milestones in surgical history. However, Professor Fontan himself was among the first to notice the palliati ve nature of the Fontan circulation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
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