Language in schizophrenia and aphasia: the relationship with non-verbal cognition and thought disorder.
Conclusion: While patients with schizophrenia and aphasia showed language impairments, the nature and cognitive basis of these impairments may be different; language performance disassociates from broader cognitive functioning in aphasia but may be an intrinsic expression of a broader cognitive impairment in schizophrenia. Thought disorder may represent a core malfunction of grammatical processing. Results suggests that communicative ability may be a valid target in cognitive remediation strategies in schizophrenia. PMID: 31550981 [PubMed - as supplied by publisher]
CONCLUSION: The criteria developed in this survey tended to be somewhat stricter than those used by other studies. The fundamental reason for this is that this survey focused on first-episode psychosis. A better understanding of each definition in first-episode psychosis is necessary to improve effective treatment outcomes. PMID: 32093460 [PubMed]
Antipsychotic medications are a vital part of controlling psychosis in schizophrenic patients. However, when those patients live in nursing facilities, we are obligated by CMS to undertake gradual dose reductions of antipsychotic medication if possible. Sometimes, these efforts are successful and sometimes they fail. Antipsychotic medications have many side effects, including sedation, diabetes, hyperlipidemia, weight gain, motor rigidity, impaired gait, and falls. Monitoring of blood glucose, lipids, and extrapyramidal symptoms is mandatory.
Cerebrovascular accident is a common diagnosis in the rehabilitation and long-term care setting and can be associated with deficits in both language and cognition. Because capacity assessment requires a patient to both understand the decision in question and express a choice, it can be particularly challenging to determine capacity in patients with aphasia. Complex medical decision-making and use of healthcare proxies in this setting require careful navigation of patient needs, goals, and rights.
The objectives of this study are: (i) to assess the frequency of self-stigma in a multicentric nonselected psychiatric rehabilitation SMI and ASD sample; and (ii) to investigate the correlates of elevated self-stigma in different SMI conditions and in ASD. METHODS.: A total of 738 SMI or ASD outpatients were recruited from the French National Centers of Reference for Psychiatric Rehabilitation cohort (REHABase). Evaluations included sociodemographic data, illness characteristics, and standardized scales for clinical severity, quality of life, satisfaction with life, wellbeing, personal recovery, a large cognitive batte...
CONCLUSIONS.: This study provided an atlas of genetic correlations between psychiatric disorders and plasma proteome, providing novel clues for pathogenetic and biomarkers, therapeutic studies of psychiatric disorders. PMID: 32093803 [PubMed - in process]
CONCLUSIONS.: Despite sharing a lower IQ and a higher prevalence of psychiatric disorders, brain abnormalities in BDo appear less pronounced (but are not absent) than in SZo. Lower ICV in SZo implies that familial risk for schizophrenia has a stronger association with stunted early brain development than familial risk for bipolar disorder. PMID: 32093799 [PubMed - in process]
Authors: Giralt-López M, Miret S, Soler J, Campanera S, Parellada M, Fañanás L, Fatjó-Vilas M Abstract BACKGROUND.: There is consistent evidence that theory of mind (ToM) is impaired in schizophrenia (SZ); however, it remains unclear whether such deficits are trait- or state-dependent. We evaluated ToM in patients with schizophrenia spectrum disorders (SSDs), their healthy first-degree relatives, and controls to test its suitability as an endophenotypic marker. We also studied the modifying effect of markers of clinical and genetic liability to SZ (schizotypy and genetic variability in t...
Authors: Morris G, Maes M, Berk M, Carvalho AF, Puri BK Abstract Nutritional ketosis, induced via either the classical ketogenic diet or the use of emulsified medium-chain triglycerides, is an established treatment for pharmaceutical resistant epilepsy in children and more recently in adults. In addition, the use of oral ketogenic compounds, fractionated coconut oil, very low carbohydrate intake, or ketone monoester supplementation has been reported to be potentially helpful in mild cognitive impairment, Parkinson's disease, schizophrenia, bipolar disorder, and autistic spectrum disorder. In these and other neurode...
Was working on our consult service and had an interesting case of substance-induced vs. first-break schizophrenia as the primary diagnosis, but during one of the interviews the patient happened to mention having the belief that his penis had been gradually retracting into his body for the past year. Further questioning seemed to be pretty spot-on with Koro as a diagnosis, but my attendings were mixed on whether this was an appropriate diagnosis because the patient was white and the culture... Koro! (and other "culture-bound" diagnoses)
Publication date: Available online 25 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): Ibrahim A. Akkouh, Thor Ueland, Lars Hansson, Elin Inderhaug, Timothy Hughes, Nils Eiel Steen, Pål Aukrust, Ole A. Andreassen, Attila Szabo, Srdjan Djurovic