October consultation #2

This patient with recurrent unilateral ocular complaints, a lid lesion, and keratitis unresponsive to numerous medications as well as a negative work-up for infectious agents leaves us with numerous diagnostic possibilities. These include: viral shedding from the lid lesion as with molluscum, eyelid deformity with corneal exposure, limbal stem cell deficiency of uncertain etiology, ocular surface dysplasia or neoplasia, superior limbic keratoconjunctivitis, vernal keratoconjunctivitis, herpes group viruses, Acanthamoeba keratitis, eyelid foreign body, medicamentosa, and many others.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Consultation section: Cataract Source Type: research

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Publication date: Available online 19 November 2019Source: Stem Cell ResearchAuthor(s): Nora Drick, Anais Sahabian, Praeploy Pongpamorn, Sylvia Merkert, Gudrun Göhring, Tobias Welte, Ulrich Martin, Ruth OlmerAbstractTumor protein p63 (p63) encodes for a transcription factor of the p53 family and is a marker for respiratory basal cells. Based on a NKX2.1 knock-in reporter cell line from human induced pluripotent stem cells (hiPSCs) (MHHi06-A-2) we established a NKX2.1/p63 double transgenic knock-in reporter cell line using TALEN technology. The reporter enables the optimization and monitoring of hiPSC differentiation t...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
TYPE 2 diabetes is a common condition that requires careful monitoring to minimise the risk of rising blood sugar levels, which can lead to deadly health complications. Luckily, certain food items offer a robust defence against rising blood sugar levels - here are five top foods.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 20 November 2019Source: Neurochemistry InternationalAuthor(s): Linlin Yuan, Shibo Sun, Xiaohan Pan, Liqin Zheng, Yuting Li, Jingyu Yang, Chunfu WuAbstractStroke is the leading cause of long-term motor disability and cognitive impairment beside the acute brain injury. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. Our previous study showed that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, isolated from leaves of Panax pseudoginseng subsp, exerted neuroprotective effects on stroke by alleviating autophagy/lysosomal defects and repres...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Publication date: Available online 19 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Sikkandhar Musafargani, Sachin Mishra, Miklós Gulyás, P. Mahalakshmi, Govindaraju Archunan, Parasuraman Padmanabhan, Balázs GulyásAbstractWith the increasing concern of neurological diseases, the improvised therapy for neurodegenerative disorders such as Alzheimer’s disease is crucial. Yet, the efficacious delivery of drug across blood-brain barrier (BBB) remains a formidable challenge. BBB acts as a gate keeper to prevent the ingress of harmful foreign agents into the brain. It has built a...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Publication date: Available online 19 November 2019Source: Carbohydrate PolymersAuthor(s): Pedro A.R. Fernandes, Carine Le Bourvellec, Catherine M.G.C. Renard, Dulcineia F. Wessel, Susana M. Cardoso, Manuel A. CoimbraAbstractGiven the high prevalence of arabinan side chains in pectic polysaccharides, this work aims to unveil the impact of their structural diversity on pectic polysaccharides-polyphenol interactions. To assess the effect of arabinan branching degree, sugar beet arabinans (branched and debranched) were used and compared to the well-known structure of apple arabinan and other pectic polysaccharides. Furthermor...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 19 November 2019Source: Carbohydrate PolymersAuthor(s): Xiaoyong Chen, Ruifen Zhang, Yizhou Li, Xiong Li, Lijun You, Viktoryia Kulikouskaya, Kseniya HileuskayaAbstractThe depolymerization effect of UV/H2O2 on the polysaccharides from Sargassum fusiforme (PSF), a brown algae, were studied. The structural changes of PSF before and after UV/H2O2 treatment were analyzed, and molecular weight changes during in vitro digestion were determined. Results indicated that the molecular weight of PSF was reduced from ∼289 to ∼12.6 kDa within 2 h with UV/150 mmol/L H2O2, an...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Astrocytes are essential for proper regulation of the central nervous system (CNS). Importantly, these cells are highly secretory in nature. Indeed they can release hundreds of molecules which play pivotal physiological roles in nervous tissues and whose abnormal regulation has been associated with several CNS disorders. In agreement with these findings, recent studies have provided exciting insights into the key contribution of astrocyte-derived signals in the pleiotropic functions of these cells in brain health and diseases. In the future, deeper analysis of the astrocyte secretome is likely to further increase our curre...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We report here a series of children who developed pulmonary hypertension after HSCT. Methods Between January 2008 and December 2015, we retrospectively analysed 366 children who underwent HSCT (age range 0.5–252 months; median 20.3 months). During the post-HSCT course, echocardiography scans motivated by respiratory symptoms identified 31 patients with elevated tricuspid regurgitation velocity (>2.8 m·s–1), confirmed when possible by right heart catheterisation (RHC). Results 22 patients had confirmed pulmonary hypertension with mean±sd pulmonary arterial pressure 40.1±1...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary vascular disease, Paediatric pulmonology Original Articles: Pulmonary hypertension and paediatrics Source Type: research
Conclusion: Overall, the results indicated from most studies that a diet with a lower percentage of obesogenic foods should be effective in reducing the risk of developing obesity. PMID: 31742427 [PubMed - as supplied by publisher]
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Today's open access paper discusses possible approaches to the treatment of immunosenescence, the age-related decline in effectiveness of the immune system. Unfortunately it is largely a tour of compensatory treatments, ways to force the cells of the immune system into greater or more useful activity without addressing any of the underlying causes of immunosenescence. Many of these methodologies have serious side-effects, are disruptive of normal immune function and overall health, and cannot be applied for the long term. Checkpoint inhibition, or the delivery of recombinant IL-7, for example, both of which are used as sho...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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