Fibrous Aggregates of Short Peptides Containing Two Distinct Aromatic Amino Acid Residues.

Fibrous Aggregates of Short Peptides Containing Two Distinct Aromatic Amino Acid Residues. Chem Biodivers. 2019 Sep 26;: Authors: Kolesinska B, Lipinski W, Wasko J, Walczak M, Fraczyk J, Kamiński ZJJ, Galecki K, Draczynski Z, Krucinska I, Kaminska M Abstract TThe aim of the study was the assessment of the ability of short peptides to form ordered fibrous aggregates under physiological conditions. Dipeptides were derived from different aromatic amino acids (heteroaromatic peptides) and tripeptides were obtained from two distinct aromatic amino acids with cysteine or methionine residue in the C-terminal, N-terminal, or central position. The ability of the peptides to form fibrous aggregates under physiological conditions was evaluated using three independent methods: the Congo Red assay, the Thioflavine T assay, and microscopic examinations using normal and polarized light. Materials potentially useful for regenerative medicine were selected based on their cytotoxicity to the endothelial cell line EA.hy 926 and physicochemical properties of films formed by peptides. The required parameters of biocompatibility were fulfilled by H-PheCysTrp-OH, H-PheCysTyr-OH, H-PheTyrMet-OH, and H-TrpTyr-OH. PMID: 31557397 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research