Rhein Augments Antiproliferative Effects of Atezolizumab Based on Breast Cancer (4T1) Regression

Planta Med DOI: 10.1055/a-1012-7034Rhein, an anthraquinone extracted from rhubarb, is used in traditional Chinese medicine for diuresis, diarrhoea, inflammation, and immune regulation. Atezolizumab, a programmed cell death ligand 1 monoclonal antibody, is mainly used to treat bladder cancer and non-small cell lung cancer unresponsive to chemotherapy. We explored the effects of rhein and atezolizumab in combination on breast cancer. Mice with established 4T1 breast cancer xenografts were administered rhein (10 mg/kg) and atezolizumab (10 mg/kg), alone and in combination, and the effects on tumour growth were evaluated. The proportion of CD8+ T cells in the spleen and tumour tissue, the levels of TNF-α, and interleukin-6 in serum as well as the mRNA levels of apoptotic factors (caspase-3, caspase-8, caspase-9, and Bax/Bcl-2) were also evaluated. All of the treatment groups had inhibitory effects on the xenograft tumour growth, with results that were significantly different from those in the control group. In addition, the proportion of CD8+ T cells in the spleen and tumour was significantly increased in the combination therapy group and was significantly different from the other treatment groups. The serum levels of TNF-α and IL-6 were significantly increased in the rhein and combination therapy groups. Finally, the levels of various apoptotic factors in tumour tissues were significantly higher in the combination treatment group than those in the other groups. A...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Tags: Reviews Source Type: research

Related Links:

What impact do antibiotic-related changes of the gut microbiome have on efficacy of immune-checkpoint inhibitors?Annals of Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
'Chinese restaurant syndrome' was coined in the 1960s and refers to headaches, nausea and sweating after eating Chinese food. Campaigners say it's a 'xenophobic myth'.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
For patients with life-altering illnesses or anyone just getting older, it helps to roll with the punches and make the best of the here and now.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cancer Elderly Books and Literature Medicine and Health Source Type: news
Observing how Chinese 2- and 3-year-olds navigated a second language, I wondered whether I could have done this for my children.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Children and Childhood Bilingual Education China Language and Languages Day Care Centers English Language Source Type: news
Men with early stage prostate cancer did not show benefits from a vegetable-rich diet.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Prostate Gland Prostate Cancer Vegetables Diet and Nutrition Prostate Specific Antigen Source Type: news
Bundled up in winter clothes as they head home for the Lunar New Year holiday amid a health scare over a mystery new virus, Chinese travelers on the teeming concourse of Beijing West station were evenly split between the masked and the barefaced.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
China has reported a sharp rise in the number of people infected with a new coronavirus, including the first cases in the capital
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
An outbreak of a new coronavirus in China has spread to more cities, Chinese authorities said on Monday, as the number of patients tripled and a third person died, stoking concerns about containment of the illness.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Chinese authorities and the World Health Organization (WHO) say a new strain of coronavirus is behind the outbreak of pneumonia in the central city of Wuhan, which has erupted just ahead of the Lunar New Year, the country's biggest festival.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The number of cases of the respiratory illness triples, as patients reported in Beijing and Shenzhen.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
More News: Bladder Cancer | Breast Cancer | Cancer | Cancer & Oncology | Chemotherapy | China Health | Diarrhoea | Drugs & Pharmacology | Lung Cancer | Non-Small Cell Lung Cancer | Rhubarb