Systems analysis-based assessment of post-treatment adverse events in lymphatic filariasis

Conclusions/SignificanceThis is the first global study of changes in gene expression associated with AEs after treatment of lymphatic filariasis. Changes in cytokines were consistent with prior studies and with the RNAseq data. These results suggest thatWolbachia lipoprotein is involved in AE development, because it activates TLR2-TLR6 and downstream NF- κB. Additionally, LPS Binding Protein (LBP, which shuttles lipoproteins to TLR2) increased post-treatment in individuals with AEs. Improved understanding of the pathogenesis of AEs may lead to improved management, increased MDA compliance, and accelerated LF elimination.

Source: PLoS Neglected Tropical Diseases - September 25, 2019 Category: Tropical Medicine Authors: Britt J. Andersen Source Type: research