Yosemite makeover seeks to keep hantavirus at bay

Last year, three visitors died and six became ill when they were infected by the rodent-borne illness. The park has spent millions working to mouse-proof lodging.YOSEMITE NATIONAL PARK — Sisters Lauren Scott and Patrice Fambrini stood near the check-in desk of Curry Village, a quaint collection of tents and cabins in Yosemite National Park, and considered the merits of their lodgings.
Source: L.A. Times - Health - Category: Consumer Health News Source Type: news

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We examined the transmission of SNV between deer mice and found that direct contact between deer mice is the main driver of SNV transmission rather than exposure to contaminated excreta/secreta, which is thought to be the main driver of transmission of the virus to humans. Furthermore, increases in heat shock responses or testosterone levels in SNV-infected deer mice do not increase the replication, shedding, or rate of transmission. Here, we have demonstrated a model for the transmission of SNV between deer mice, the natural rodent reservoir for the virus. The use of this model will have important implications for further...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Huaiyu Tian, Nils Chr. Stenseth Hantaviruses can cause hantavirus pulmonary syndrome (HPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. In recent decades, repeated outbreaks of hantavirus disease have led to public concern and have created a global public health burden. Hantavirus spillover from n atural hosts into human populations could be considered an ecological process, in which environmental forces, behavioral determinants of exposure, and dynamics at the human–animal interface affect human susceptibility and the epidemiology of the disease. In this review, we summarize the p...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Moritz Saxenhofer, Sabrina Schmidt, Rainer G. Ulrich, Gerald Heckel The diversity of viruses probably exceeds biodiversity of eukaryotes, but little is known about the origin and emergence of novel virus species. Experimentation and disease outbreak investigations have allowed the characterization of rapid molecular virus adaptation. However, the processes leading to the establishment of functionally distinct virus taxa in nature remain obscure. Here, we demonstrate that incipient speciation in a natural host species has generated distinct ecological niches leading to adaptive isolation in an RNA virus. We found a very...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Viruses, Vol. 11, Pages 169: A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility Viruses doi: 10.3390/v11020169 Authors: Constanza Martínez-Valdebenito Jenniffer Angulo Nicole Le Corre Claudia Marco Cecilia Vial Juan Francisco Miquel Jaime Cerda Gregory Mertz Pablo Vial Marcelo Lopez-Lastra Marcela Ferrés The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recogn...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The potential effect of the inactivated hantavirus vaccine (IHV) remains controversial; however, it appears to be moderately effective for patients at high risk of hemorrhagic fever with renal syndrome (HFRS)....
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
This study suggests that elevated DMP1 concentrations may be associated with disease stage, severity, and the degree of acute kidney injury. DMP1 is involved in the regulation of capillary permeability in HFRS caused by hantavirus infection.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Purpose: Background: Puumala hantavirus (PUUV) can cause hemorrhagic fever with renal syndrome (HFRS), an acute infection characterized by hemorrhages and kidney insufficiency. The Volga Federal District, including the Republic of Tatarstan (RT), is the most active zoonotic region where HFRS accounts for 83.3% of all zoonotic registered cases. Although PUUV is identified as the main infectious agent, little is known about the genetic variability of PUUV in the RT.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 08.010 Source Type: research
Purpose: Tula hantavirus (TULV) is zoonotic virus widespread across Eurasia, where numerous small mammal species have been shown to be its reservoirs. In the Balkans, Serbia is the first country where TULV was detected, in European pine vole, M. subterraneus trapped in 1987. Although TULV is not considered pathogenic for humans, cases of human infection have been reported on several occasions so far.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.089 Source Type: research
Purpose: Hantaviruses (Hantaviridae) cause two types of life-threatening human diseases, hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. To date, as a consensus, wild rodents were believed as natural hosts of hantaviruses. However, recent studies described several novel hantaviruses in shrews, moles and bats, suggesting the dispersal of hantaviruses in several animal taxa during their evolution. Interestingly, the co-evolutionary analyses of most recent studies have raised the possibility of bats and/or soricomorphs may have served as the primordial ma...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.078 Source Type: research
Purpose: Background: Puumala hantavirus (PUUV) is the main cause of hemorrhagic fever with renal syndrome (HRFS) in Russia. Although known to cause HFRS endemic in the Republic of Tatarstan (RT), little is known about the genetic diversity of PUUV in the Republic. Therefore, we sought to characterize variations in PUUV S-segment in bank voles in the RT.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.077 Source Type: research
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