Symposium Featured Pediatric Device Awards, Discussed Clinical Trial Possibilities

Six of the finalists competing in the “Make Your Medical Device Pitch for Kids!” program by Children’s National Hospital and the National Capital Consortium for Pediatric Device Innovation (NCC-PDI) were selected as winners during the 7th Annual Pediatric Device Innovation Symposium. Each company earned a $25,000 award and the opportunity to participate in NCC-PDI’s recently launched “Pediatric Device Innovator Accelerator Program” led by MedTech Innovator. In addition to celebrating pediatric device innovation, the symposium also encouraged a better understanding of clinical trials for pediatric devices as well as awareness of the regulatory challenges. The award-winning pediatric devices and companies are: AlgometRx Inc.'s AlgometRx Rapid Drug Test, used to detect and monitor neonatal abstinence syndrome. It aims to enable earlier assessment and intervention of opioid withdrawal to reduce physiological stress. Epitel's Epilog, an inexpensive, discrete, and disposable EEG machine offering real-time monitoring to help manage care for neonates suspected of hypoxic-ischemic encephalopathy. Novonate's LifeBubble, designed to secure and protect the umbilical catheter insertion site for neonates in intensive care with the goal of preventing infection from caregivers and parents. PyrAmes Inc.'s noninvasiv...
Source: MDDI - Category: Medical Devices Authors: Tags: Design Source Type: news

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ConclusionsSome rare pathophysiological relationships between intracranial hypotension and cervical myelopathy, can be difficult for diagnosis. Our findings indicate that proper diagnosis of such relationships after CSF shunt placement can provide relief of myelopathic symptoms.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Alcyone Lifesciences is a medical technology company based out of Lowell, MA, which specializes in central nervous system (CNS) drug delivery platforms for targeted infusions of the brain or spinal cord. Their Thecaflex DRx System was recently awarde...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Neurosurgery Pain Management Psychiatry Source Type: blogs
This study aimed to investigate a potential correlation between NGF serum levels and brain structural differences in schizophrenia. Furthermore, a potential overlap between the results of a whole brain correlation analysis between GMV and NGF serum levels and the results of GMV reductions in schizophrenia patients were identified in a conjunction analysis.Materials and MethodsSubjectsEighteen schizophrenia patients from the Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, Aachen, Germany, and 19 gender- and age-matched healthy controls from the general population participated in ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 11 December 2018Source: Brain, Behavior, and ImmunityAuthor(s): Clara López-Serrano, Eva Santos-Nogueira, Isaac Francos-Quijorna, Marina Coll-Miro, Jerold Chun, Rubèn López-ValesAbstractLysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled receptors (LPA1-LPA6). In the central nervous system (CNS), LPA mediates a wide range of effects, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and contribution...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
pez-Vales R Abstract Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions by signaling through six known G-protein-coupled receptors (LPA1-LPA6). In the central nervous system (CNS), LPA mediates a wide range of effects, including neural progenitor cell physiology, astrocyte and microglia activation, neuronal cell death, axonal retraction, and contributions to pain, schizophrenia and hydrocephalus. We recently reported that LPA-LPA1 signaling mediates functional deficits and myelin loss after spinal cord injury (SCI). Here, we provide clear evidence on the deleter...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
ConclusionEarly recognition of CVJ pathology and hydrocephalus is critical to avoid the development of severe complications. A multidisciplinary approach involving physicians, neuroradiologists, and neurosurgeons is needed to detect such conditions and to select patients eligible for surgery.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
We report a case of serious neurologic injury due to inadvertent epidural injection of 8 ml of the antiseptic 2% chlorhexidine in 70% alcohol during a procedure aimed to relieve the pain of labour. This resulted in immediate severe back pain, progressive tetraparesis and sphincter dysfunction caused by damage to the spinal cord and nerve roots. Subacute hydrocephalus necessitated drainage, but cranial nerve and cognitive function were spared. Magnetic resonance imaging documented marked abnormality of the spinal cord and surrounding leptomeninges. In the ensuing eight years, there has been clinical and electrophysiological...
Source: Anaesthesia and Intensive Care - Category: Anesthesiology Source Type: research
Conclusions: Systematic follow-up of patients with a history of fSBR revealed a high incidence of IC. Whether these are of dysembryogenic or iatrogenic origin, remains unclear. Since both IC per se and IC resection may lead to loss of neurologic function, IC can be considered a “third hit.”Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research
CONCLUSIONS: The diagnoses were made early based on clinical and radiographic findings. All cases were confirmed molecularly. Despite presenting a benign course, it is necessary to establish a systematic protocol for the surveillance of these patients due to the common clinical intercurrences.
Source: Clinics - Category: General Medicine Source Type: research
Discussion VATER association was first described in the 1970s with additional congenital malformations being added to the association so it is most often called VACTERL association. It is a highly heterogeneous, overlapping condition estimated to occur in ~1/10,000-40,000 births. The cause is unknown. In animal models, some signaling pathway gene mutations have phenotypes of VACTERL association. Experts suggest that patients having at least 2 components should be further evaluated (at least 3 for diagnosis) for VACTERL and other diseases in its differential diagnosis. There are more than 30 syndromes, mutations and diseas...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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