Design, crystal structures and sustainable synthesis of family of antipyrine derivatives: Abolish to bacterial and parasitic infection

Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Gurjaspreet Singh, Pinky Satija, Baljinder Singh, Shweta Sinha, Rakesh Sehgal, Subash Chandra SahooAbstractThis work explores the facile synthesis of a series of antipyrine acetylinic framework (3a-3h). The newly synthesized compounds are recognized by IR, NMR (1H, 13C), X-ray diffraction. This collection played indispensable role in the development of biologically active agents. Our goal is to enable adoption of green chemistry within the pharmaceutical industry for the benefit of society, industry and the environment. This work articulates a new possible scaffold for drug discovery against protozoal pathogens (Entamoeba histolytica and Giardia lamblia) and bacterial strain (Staphylococcus aureus, Vibrio cholera, E. coli, Bacillus subtillus). The purpose of the present undertaking is to put low price anti parasitic drug using green technology. It is envisaged that the alliance of anti pyrine derivative and acetylene framework into a single scaffold boosts the effectiveness of anti bacterial as well as anti-parasitic treatment and may be vital for meeting future challenges in medicinal world.Graphical abstract
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research