Stereotactic body radiation therapy and immunotherapy.

This article reviews the association between the immune system and cancer, as well as the additional systemic benefit that SBRT can have in patients with advanced-stage malignancies being treated with immunotherapy. PMID: 31549973 [PubMed - in process]
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research

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The objective of the present study was to identify potential genes associated with melanoma progression and to explore approved therapeutic drugs that target these genes. Weighted gene co-expression network analysis was used to construct a gene co-expression network, explore the associations between genes and clinical characteristics and identify potential biomarkers. Gene expression profiles of the GSE65904 dataset were obtained from the Gene Expression Omnibus database. RNA-sequencing data and clinical information associated with melanoma obtained from The Cancer Genome Atlas were used for biomarker validation. A total o...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 3 December 2019Source: Pharmacological ResearchAuthor(s): Soraya Sajadimajd, Roodabeh Bahramsoltani, Amin Iranpanah, Jayanta Kumar Patra, Gitishree Das, Sushanto Gouda, Roja Rahimi, Elnaz Rezaeiamiri, Hui Cao, Francesca Giampieri, Maurizio Battino, Rosa Tundis, Maria G. Campos, Mohammad Hosein Farzaei, Jianbo XiaoAbstractPolyphenols are one of most important phytochemicals distributing in herb plants, vegetables and fruits, which known as important anticancer agents. Given the high incidence and mortality of skin cancer, this study aimed to uncover the chemopreventive effects of polypheno...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ef Zakharia We reviewed the literature to assess the efficacy and risk of constitutional, cardiac, gastrointestinal, and dermatological toxicities of combined BRAF plus MEK inhibitors versus BRAF inhibitors alone in patients with metastatic melanoma with BRAF mutations. Searches were conducted in PubMed, Cochrane Database of Systematic Reviews, Google scholar, ASCO, Scopus, and EMBASE for reports published from January 2010 through March 2019. Efficacy, including progression-free survival (PFS) and overall survival (OS) rates, were assessed by hazard ratio (HR); objective response rates (ORR) were assessed by odds rati...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
This study describes a randomised control trial investigating whether printed leaflets or social media are more effective in increasing knowledge of the risks of sun exposure and melanoma in people aged 18–29. The study participants were 18–29-year-old university students or graduates, recruited in London. A baseline level of knowledge was measured using the Skin Cancer and Sun Knowledge questionnaire. Study participants were then randomised into either a leaflet arm or Facebook arm. Identical information was delivered through a SunSafe campaign via either posted leaflets or Facebook during a 10-day exposure wi...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Skin Cancer Source Type: research
(American Friends of Tel Aviv University) Tel Aviv University's Prof. Carmit Levy received the prestigious Young Investigator Award at the 16th International Congress of the Society for Melanoma Research, held Nov. 20-23 in Salt Lake City, Utah, for her 'contributions to melanoma research that significantly exceeded the average for this career stage.'
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b13420
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
Publication date: Available online 3 December 2019Source: Inorganica Chimica ActaAuthor(s): Luiz D. Ramos, Giselle Cerchiaro, Karina P. Morelli FrinAbstractIn this work, fac-[Re(et-isonic)(NN)(CO)3]+ complexes, et-isonic = ethyl-isonicotinate, NN = 1,10-phenanthroline (phen), 4,7-diphenyl-1,10-phenanthroline (Ph2phen), 4,7-dichloro-1,10-phenanthroline (Cl2phen) or 4,7-dimethyl-1,10-phenanthroline (Me2phen), were synthesized to combine different substituent groups at coordinate phen ligand along with the coordination of a nicotinic acid derivative aiming the modulation of the photophysical and lipophilic properties. The ele...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Tije Vreugdenhil Hoeven Wouters The prognosis of patients with advanced melanoma has improved dramatically. However, the clinical outcomes of patients with highly elevated serum lactate dehydrogenase (LDH) remain very poor. The aim of this study was to explore whether patients with normalized LDH after targeted therapy could benefit from subsequent treatment with immune checkpoint inhibitors (ICI). Data from all patients with BRAF-mutant metastatic melanoma with a highly elevated serum LDH at baseline (≥2× upper limit of normal) receiving first-line targeted therapy between 2012 and 2019 in th...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conditions:   Uveal Melanoma;   Metastatic Cancer Interventions:   Drug: Cediranib Maleate;   Drug: Durvalumab Sponsors:   Grupo Español Multidisciplinar de Melanoma;   MFAR Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Keserű Richard Moriggl Signal transducer and activator of transcription (STAT)3 and STAT5 are important transcription factors that are able to mediate or even drive cancer progression through hyperactivation or gain-of-function mutations. Mutated STAT3 is mainly associated with large granular lymphocytic T-cell leukemia, whereas mutated STAT5B is associated with T-cell prolymphocytic leukemia, T-cell acute lymphoblastic leukemia and γδ T-cell-derived lymphomas. Hyperactive STAT3 and STAT5 are also implicated in various hematopoietic and solid malignancies, such as chronic and acute myeloid leukem...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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