A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes.
A Brief Review of Cardiovascular Diseases, Associated Risk Factors and Current Treatment Regimes. Curr Pharm Des. 2019 Sep 25;: Authors: Flora GD, Nayak MK Abstract Cardiovascular diseases (CVDs) are the leading cause of premature death and disability in humans and their incidence is on the rise globally. Given their substantial contribution towards the escalating costs of health care, they also generate a high socio-economic burden in the general population. The underlying pathogenesis and progression associated with nearly all CVDs is predominantly of atherosclerotic origin that leads to the development of coronary artery disease, cerebrovascular disease, venous thromboembolism and, peripheral vascular disease, subsequently causing myocardial infarction, cardiac arrhythmias or stroke. The aetiological risk factors leading to the onset of CVDs are well recognized and include hyperlipidaemia, hypertension, diabetes, obesity, smoking and, lack of physical activity. They collectively represent more than 90% of the CVD risks in all epidemiological studies. Despite the critical fatality rate of CVDs, the identification and careful prevention of the underlying risk factors can significantly reduce the global epidemic of CVDs. Primary regimes for the prevention and treatment of CVDs include lipid-lowering drugs, antihypertensives, antiplatelet and anticoagulation therapies. Despite their effectiveness, significant gaps in the treatment of CVDs remain. In this ...
Conclusion: The GFD-PCS measures patient-perceived dietary competence for maintaining a GFD. The scale is psychometrically robust and provides a useful tool in assessing patients' difficulties with a GFD. PMID: 31738623 [PubMed - as supplied by publisher]
Publication date: Available online 18 November 2019Source: PeptidesAuthor(s): Rabeet Khan, Alejandra Tomas, Guy A. RutterAbstractGlucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin that, in common with glucagon-like peptide-1 (GLP-1), has both insulin releasing and extra-pancreatic glucoregulatory actions. GIP is released in response to glucose or fat absorption and acts on the GIP receptor (GIPR) to potentiate insulin release from pancreatic beta cells. GIP has also been shown to promote beta cell survival and stimulate the release of GLP-1 from islet alpha cells. There is now evidence to suggest ...
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ04551A, PaperYitong Xie, Di Wei, Tian Hu, Yajing Hou, Yuanyuan Lin, Huaizhen He, Cheng Wang Uncaria rhynchophylla (UR) is a widely used traditional Chinese herb for hyperpyrexia, epilepsy, preeclampsia, and hypertension. In this paper, the potential anti-pseudo-allergic components in UR were explored. Six alkaloids in... The content of this RSS Feed (c) The Royal Society of Chemistry
Journal of Endourology, Ahead of Print.
AIMS: Sensory loss and impaired balance are considered risk factors of incident falls. The aim of this study was to assess the relationship between degree of foot sensation and balance, risk of falls, incidence of fall-related injuries and costs in a cohor...
ConclusionAMI as a result of penetrating trauma is rare, but can occur secondary to an acute thrombus, even in the absence of a direct cardiac injury. MI should be a consideration in patients with penetrating trauma to the chest, regardless of the intensity of the trauma. At minimum, a 12-lead electrocardiogram (ECG) and a baseline troponin should be obtained at initial evaluation and post-operatively, if surgically managed. If ECG demonstrates findings concerning for MI, it should be followed with an echocardiogram and/or cardiac angiogram to further help guide management, with an early cardiology consultation.
The use of frequent debridement along with active continuous diffusion of oxygen therapy may be associated with better outcomes.Wounds
Bariatric surgery may help reduce the recurrence of atrial fibrillation after ablation among obese patients, but it is not without risk. Do the benefits outweigh the risks?Europace
Authors: Borgel D, Bianchini E, Lasne D, Pascreau T, Saller F Abstract Deep vein thrombosis is a common disease associated with a variety of complications including post-thrombotic syndrome as a late complication. It is now clear that in addition to classical deep vein thrombosis triggers such as blood flow disturbance, hypercoagulability, and vessel wall changes, inflammation has a key role in the pathophysiology of deep vein thrombosis, and there is a close relationship between inflammation and coagulation. As attested by changes in several plasma biomarkers, inflammation may have a significant role in the develo...
The most common treatment against migraine is unsafe for people at risk of cardiovascular disease and stroke, but a new drug against migraine has shown promise in a large-scale clinical trial, offering hope of an alternative treatment.
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