Overcoming Drew’s blood disorder, together
When Jen’s son Drew was diagnosed with aplastic anemia, a blood disorder, their entire lives changed. In this blog, Jen describes how she and Drew coped with the disease, treatment and recovery, as well as the care they both received at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. (Click the link to see the center’s new website.) By Jen D’Auteuil Jen and her son Drew When my son Drew was diagnosed with aplastic anemia (AA) at 10 years old, our lives turned upside down. His bone marrow had stopped producing the cells that he needed for iron and oxygen transfers, for blood clotting and fighting off infection, making him very sick very quickly. All of a sudden my active and social little guy was sidelined—he tired easily and was at constant risk of bleeding or getting sick, so he needed to be kept away from almost everyone he knew. He was started on a chemotherapy regimen called anti-thymocyte globulin (ATG), which doctors hoped would reactivate his bone marrow. In the meantime, Drew and our family went into isolation because he couldn’t be in public places, and we had to ban visitors from our home. Our only real contact with the outside world was by texting. (Something I had never bothered with; but a little time in isolation can change your mind!) For the next few months we had to sit in this medical exile to see if the AGT did its job. It was a difficult time, but we were very fortunate to have a supportive and gene...
This study compares the cost-effectiveness of routine versus selective pre-procedure INR testing.
To analyze a prospective cohort of patients undergoing routine image-guided bone and soft tissue biopsies of the extremities using revised criteria for requiring preprocedural lab tests (CBC and INR) and stopping aspirin. 1. The aim was to assess whether the revised criteria resulted in an increased bleeding complication rate. 2. To evaluate if the revised criteria would decrease the time from the biopsy being ordered to when the biopsy was performed.
Pre-procedure correction coagulopathy is of high priority in patients undergoing minimally invasive IR procedures. Unnecessary transfusion of blood products is associated with well-known infectious and non-infectious risks, however, uncorrected coagulopathy in the perioperative setting can be detrimental to the patient. Therefore, determining safe thresholds for administration of blood products is imperative, which in interventional radiology is mostly governed by the SIR consensus guidelines. The purpose of this study is to assess whether a single institution ’s restrictive approach to pre-procedural transfusion of ...
The objective of this compound is to decrease the rate of rectal toxicity related to radiation therapy, by creating a gap between the prostate and rectum. Secondary benefits include decreased urinary complications and improved sexual quality of life. The hydrogel spacer maintains space for approximately 3 months, and is absorbed in about 6 months.
To evaluate the efficacy and clinical impact of 3 Tesla in-bore trans-rectal magnetic resonance-guided biopsy (3T MRGB) for prostate cancer (PCa) detection based on PIRADSv2 in patients with either suspected prostate cancer or under active surveillance.
Many patients with mucinous peritoneal tumours achieve long-term recurrence free and overall survival from cytoreductive surgery and intraperitoneal chemotherapy, however recurrence is frequently seen. Repeat surgical interventions have a negative impact on quality of life, risks may outweigh any potential benefits and repeated admissions have a considerable impact on healthcare systems. The deconditioned patient is eventually deemed inoperable with no treatment option for their disease. In an attempt to modify these outcomes, we discovered remarkable synergy in extensive preclinical studies between Bromelain (Br) and Acetylcysteine (NAC).
To assess the feasibility of selective delivery of chemotherapy in lung using a double balloon occlusion catheter in subsegmental pulmonary arteries (PA) to increase tissue drug concentrations relative to intravenous (IV) administration.
We describe our experience using MRI fused CBCT guidance for prostate biopsy. There are no published reports on the use of CBCT guidance in prostate biopsies. We hypothesize this technique will have an adequate safety profile while accurately detecting prostate cancer.
Image-guided thermal ablation has become the standard of care for treating early stage liver cancer. However, a significant limitation to a successful ablation procedure is the heat-sink effect, which may lead to suboptimal thermal dose delivery. Currently, there is no reliable method for quantifying the heat-sink effect due to limited information on blood vessel flow and its associated anatomy relative to the ablation zone. The purpose of this study was to use 4D-flow MRI to map out liver flow patterns and correlate flow rates with ablation zone volumes.
To access the technical success, efficacy, and potential complications of the combination of transarterial embolization (TAE) followed by percutaneous image-guided ablation (cryoablation or radiofrequency ablation) in the treatment of stage T1B and central renal cell carcinomas (RCC).
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