Cyclic Glycine-Proline Normalizes Systolic Blood Pressure in High-fat Diet-Induced Obese Male Rats

Insulin-like growth factor (IGF)-1 deficiency is associated with a range of metabolic disorders. Cyclic glycine-proline (cGP) is a natural nutrient and regulates the amount of active IGF-1 in plasma. Plasma cGP decreases in hypertensive women whereas increases in obese women, suggesting its involvement in cardio-metabolic function. We therefore examined the effects of cGP on metabolic profiles and blood pressure in high-fat diet (HFD)-induced obese male rats.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 24, 2019 Category: Nutrition Authors: Fengxia Li, Karen Liu, Clint Gray, Paul Harris, Clare M. Reynolds, Mark H. Vickers, Jian Guan Source Type: research